CACNA1H
Gene Ontology Biological Process
- aldosterone biosynthetic process [IMP]
- axon guidance [TAS]
- calcium ion import [IDA]
- cellular response to hormone stimulus [IEP]
- cellular response to potassium ion [IEP]
- cortisol biosynthetic process [IMP]
- membrane depolarization during action potential [IBA]
- muscle contraction [TAS]
- muscle organ development [NAS]
- myoblast fusion [TAS]
- positive regulation of acrosome reaction [IMP]
- regulation of heart contraction [TAS]
- regulation of membrane potential [IDA]
- transport [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
KLHL1
Gene Ontology Biological Process
Gene Ontology Molecular Function
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
T-type current modulation by the actin-binding protein Kelch-like 1.
We report a novel form of modulation of T-type calcium currents carried out by the neuronal actin-binding protein (ABP) Kelch-like 1 (KLHL1). KLHL1 is a constitutive neuronal ABP localized to the soma and dendritic arbors; its genetic elimination in Purkinje neurons leads to dendritic atrophy and motor insufficiency. KLHL1 participates in neurite outgrowth and upregulates voltage-gated P/Q-type calcium channel function; ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID