BAIT
KATNA1
katanin p60 (ATPase containing) subunit A 1
GO Process (2)
GO Function (4)
GO Component (7)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
NDEL1
2600006O07Rik, MITAP1, NUDEL, mNudel, RP23-396M19.4
nuclear distribution gene E-like homolog 1 (A. nidulans)
GO Process (24)
GO Function (6)
GO Component (13)
Gene Ontology Biological Process
- activation of Cdc42 GTPase activity [IDA]
- canonical Wnt signaling pathway [IMP]
- cell migration [IMP]
- central nervous system neuron axonogenesis [IMP]
- centrosome localization [IMP]
- cerebral cortex radially oriented cell migration [IMP]
- chromosome segregation [IBA, ISO]
- establishment of chromosome localization [IBA]
- establishment of mitotic spindle orientation [IBA]
- inner cell mass cell proliferation [IMP]
- microtubule cytoskeleton organization [IGI]
- microtubule nucleation [IBA]
- mitotic centrosome separation [IGI, IMP]
- neurofilament cytoskeleton organization [IMP]
- neuron migration [IGI]
- neuron projection development [ISO]
- neuron projection extension [IGI]
- nuclear envelope disassembly [ISS]
- positive regulation of axon extension [ISO]
- positive regulation of axon regeneration [ISO]
- proteolysis [ISO]
- regulation of neuron projection development [IMP, ISO]
- retrograde axon cargo transport [IDA]
- vesicle transport along microtubule [IGI]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Recruitment of katanin p60 by phosphorylated NDEL1, an LIS1 interacting protein, is essential for mitotic cell division and neuronal migration.
LIS1 is mutated in the human neuronal migration defect lissencephaly and along with NDEL1 (formerly NUDEL) participates in the regulation of cytoplasmic dynein function during neuronal development. Targeted disruption of Ndel1 suggested that NDEL1 could have other molecular targets that regulate microtubule organization for proper neuronal migration. To further understanding the molecular mechanism of LIS1 and lissencephaly, we identified the ... [more]
Hum. Mol. Genet. Nov. 01, 2005; 14(21);3113-28 [Pubmed: 16203747]
Throughput
- Low Throughput
Curated By
- BioGRID