BAIT

NEU1

NANH, NEU, SIAL1, DAAP-222I20.1
sialidase 1 (lysosomal sialidase)
Homo sapiens
PREY

KCNA4

HBK4, HK1, HPCN2, HUKII, KCNA4L, KCNA8, KV1.4, PCN2
potassium voltage-gated channel, shaker-related subfamily, member 4
UPS Project
Homo sapiens

Biochemical Activity (Proteolytic Processing)

An interaction is inferred from the biochemical effect of one protein upon another, for example, GTP-GDP exchange activity or phosphorylation of a substrate by a kinase. The bait protein executes the activity on the substrate hit protein. A Modification value is recorded for interactions of this type with the possible values Phosphorylation, Ubiquitination, Sumoylation, Dephosphorylation, Methylation, Prenylation, Acetylation, Deubiquitination, Proteolytic Processing, Glucosylation, Nedd(Rub1)ylation, Deacetylation, No Modification, Demethylation.

Publication

Subunit composition determines Kv1 potassium channel surface expression.

Manganas LN, Trimmer JS

Shaker-related or Kv1 voltage-gated K(+) channels play critical roles in regulating the excitability of mammalian neurons. Native Kv1 channel complexes are octamers of four integral membrane alpha subunits and four cytoplasmic beta subunits, such that a tremendous diversity of channel complexes can be assembled from the array of alpha and beta subunits expressed in the brain. However, biochemical and immunohistochemical ... [more]

J. Biol. Chem. Sep. 22, 2000; 275(38);29685-93 [Pubmed: 10896669]

Throughput

  • Low Throughput

Curated By

  • BioGRID