PIN1
Gene Ontology Biological Process
- cytokine-mediated signaling pathway [TAS]
- innate immune response [TAS]
- negative regulation of ERK1 and ERK2 cascade [IDA]
- negative regulation of cell motility [IDA]
- negative regulation of transforming growth factor beta receptor signaling pathway [IDA]
- negative regulation of type I interferon production [TAS]
- positive regulation of Rho GTPase activity [IMP]
- positive regulation of protein phosphorylation [IGI]
- positive regulation of ubiquitin-protein transferase activity [IDA]
- protein peptidyl-prolyl isomerization [IDA]
- regulation of cytokinesis [IGI, IMP]
- regulation of mitosis [TAS]
- regulation of pathway-restricted SMAD protein phosphorylation [IDA]
Gene Ontology Molecular Function
TP73
Gene Ontology Biological Process
- DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator [IBA]
- cellular response to DNA damage stimulus [IDA]
- cellular response to UV [IBA]
- intrinsic apoptotic signaling pathway in response to DNA damage [TAS]
- intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [IBA, IDA]
- mismatch repair [TAS]
- mitotic G1 DNA damage checkpoint [IBA]
- negative regulation of JUN kinase activity [IBA]
- negative regulation of cardiac muscle cell proliferation [IMP]
- negative regulation of neuron apoptotic process [IBA]
- negative regulation of transcription from RNA polymerase II promoter [IBA]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- positive regulation of transcription, DNA-templated [IDA]
- regulation of gene expression [IMP]
- regulation of mitotic cell cycle [IMP]
- response to X-ray [IBA]
- response to gamma radiation [IBA]
Gene Ontology Molecular Function- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- chromatin binding [IBA]
- damaged DNA binding [IBA]
- double-stranded DNA binding [IBA]
- identical protein binding [IPI]
- p53 binding [IBA]
- protein binding [IPI]
- protein kinase binding [IPI]
- sequence-specific DNA binding transcription factor activity [IDA]
- transcription factor binding [IPI]
- transcription regulatory region DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- chromatin binding [IBA]
- damaged DNA binding [IBA]
- double-stranded DNA binding [IBA]
- identical protein binding [IPI]
- p53 binding [IBA]
- protein binding [IPI]
- protein kinase binding [IPI]
- sequence-specific DNA binding transcription factor activity [IDA]
- transcription factor binding [IPI]
- transcription regulatory region DNA binding [IDA]
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Pin1 links the activities of c-Abl and p300 in regulating p73 function.
Activation of p73 upon genotoxic treatment triggers apoptosis of tumor cells lacking functional p53 and involves the activities of c-Abl and p300. Here, we demonstrate that conformational changes of p73 catalyzed by the prolyl isomerase Pin1 are crucial in this pathway. Lack of Pin1 reduces p73 stability, hampering its accumulation upon genotoxic stress. Indeed, we show that upon treatment with ... [more]
Throughput
- Low Throughput
Related interactions
Curated By
- BioGRID