CDK7
Gene Ontology Biological Process
- 7-methylguanosine mRNA capping [TAS]
- ATP catabolic process [IDA]
- DNA repair [TAS]
- G1/S transition of mitotic cell cycle [TAS]
- G2/M transition of mitotic cell cycle [TAS]
- androgen receptor signaling pathway [NAS]
- cell cycle arrest [TAS]
- cell proliferation [TAS]
- gene expression [TAS]
- mitotic cell cycle [TAS]
- nucleotide-excision repair [TAS]
- nucleotide-excision repair, DNA damage removal [TAS]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- positive regulation of transcription, DNA-templated [NAS]
- positive regulation of viral transcription [TAS]
- regulation of cyclin-dependent protein serine/threonine kinase activity [TAS]
- termination of RNA polymerase I transcription [TAS]
- transcription elongation from RNA polymerase I promoter [TAS]
- transcription elongation from RNA polymerase II promoter [TAS]
- transcription from RNA polymerase I promoter [TAS]
- transcription from RNA polymerase II promoter [IDA, TAS]
- transcription initiation from RNA polymerase I promoter [TAS]
- transcription initiation from RNA polymerase II promoter [TAS]
- transcription-coupled nucleotide-excision repair [TAS]
- viral process [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
CDK6
Gene Ontology Biological Process
- G1/S transition of mitotic cell cycle [TAS]
- astrocyte development [ISS]
- cell cycle arrest [TAS]
- cell dedifferentiation [IMP]
- dentate gyrus development [ISS]
- generation of neurons [ISS]
- gliogenesis [IMP]
- lateral ventricle development [ISS]
- mitotic cell cycle [TAS]
- negative regulation of cell cycle [IDA]
- negative regulation of cell differentiation [TAS]
- negative regulation of cell proliferation [TAS]
- negative regulation of cellular senescence [IDA]
- negative regulation of epithelial cell proliferation [IMP]
- negative regulation of myeloid cell differentiation [IDA]
- negative regulation of osteoblast differentiation [IDA]
- positive regulation of cell-matrix adhesion [IDA]
- positive regulation of fibroblast proliferation [IMP]
- protein phosphorylation [IDA]
- regulation of cell motility [ISS]
- regulation of erythrocyte differentiation [IMP]
- regulation of gene expression [IDA, IMP]
- response to virus [IEP]
- type B pancreatic cell development [IDA]
Gene Ontology Molecular Function
Biochemical Activity (Phosphorylation)
An interaction is inferred from the biochemical effect of one protein upon another, for example, GTP-GDP exchange activity or phosphorylation of a substrate by a kinase. The bait protein executes the activity on the substrate hit protein. A Modification value is recorded for interactions of this type with the possible values Phosphorylation, Ubiquitination, Sumoylation, Dephosphorylation, Methylation, Prenylation, Acetylation, Deubiquitination, Proteolytic Processing, Glucosylation, Nedd(Rub1)ylation, Deacetylation, No Modification, Demethylation.
Publication
Both p16 and p21 families of cyclin-dependent kinase (CDK) inhibitors block the phosphorylation of cyclin-dependent kinases by the CDK-activating kinase.
Phosphorylation of cyclin-dependent kinases (CDKs) by the CDK-activating kinase is required for the activation of CDK enzymes. Members of two families of CDK inhibitors, p16/p18 and p21/p27, become physically associated with and inhibit the activity of CDKs in response to a variety of growth-modulating signals. Here, we show that the representative members of both families of CDK inhibitors, p21waf1,cip1, p27kip1, ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID