GNB1
Gene Ontology Biological Process
- G-protein coupled receptor signaling pathway [IDA, ISO, TAS]
- GTP catabolic process [ISA, ISO]
- cardiac muscle cell apoptotic process [ISO]
- cell proliferation [IDA]
- cellular response to hypoxia [ISO]
- phospholipase C-activating G-protein coupled receptor signaling pathway [IDA]
- phototransduction, visible light [ISA]
- positive regulation of cytosolic calcium ion concentration [ISO]
- retina development in camera-type eye [IMP]
- sensory perception of taste [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
GNB2L1
Gene Ontology Biological Process
- activation of cysteine-type endopeptidase activity involved in apoptotic process [ISO]
- intracellular signal transduction [ISA]
- negative regulation of cell growth [ISO]
- negative regulation of gene expression [ISO]
- negative regulation of hydrogen peroxide-induced neuron death [ISO]
- negative regulation of phagocytosis [ISO]
- negative regulation of protein kinase B signaling [ISO]
- negative regulation of protein tyrosine kinase activity [ISO]
- negative regulation of translation [ISO]
- osteoblast differentiation [ISO]
- positive regulation of GTPase activity [ISO]
- positive regulation of apoptotic process [ISO]
- positive regulation of cAMP catabolic process [ISO]
- positive regulation of cell migration [ISO]
- positive regulation of cyclic-nucleotide phosphodiesterase activity [ISO]
- positive regulation of intrinsic apoptotic signaling pathway [ISO]
- positive regulation of mitochondrial depolarization [ISO]
- positive regulation of proteasomal ubiquitin-dependent protein catabolic process [ISO]
- positive regulation of protein homooligomerization [ISO]
- positive regulation of protein phosphorylation [ISO]
- protein localization [ISA]
- regulation of cell cycle [ISO]
- regulation of establishment of protein localization to plasma membrane [ISO]
Gene Ontology Molecular Function- SH2 domain binding [ISO]
- cysteine-type endopeptidase activator activity involved in apoptotic process [ISO]
- enzyme binding [ISO]
- ion channel inhibitor activity [IDA]
- poly(A) RNA binding [ISO]
- protein binding [IPI]
- protein homodimerization activity [ISO]
- protein kinase C binding [ISA, ISO]
- protein phosphatase binding [ISO]
- protein tyrosine kinase inhibitor activity [ISO]
- receptor activity [ISA]
- receptor tyrosine kinase binding [ISO]
- SH2 domain binding [ISO]
- cysteine-type endopeptidase activator activity involved in apoptotic process [ISO]
- enzyme binding [ISO]
- ion channel inhibitor activity [IDA]
- poly(A) RNA binding [ISO]
- protein binding [IPI]
- protein homodimerization activity [ISO]
- protein kinase C binding [ISA, ISO]
- protein phosphatase binding [ISO]
- protein tyrosine kinase inhibitor activity [ISO]
- receptor activity [ISA]
- receptor tyrosine kinase binding [ISO]
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
The betagamma subunit of heterotrimeric G proteins interacts with RACK1 and two other WD repeat proteins.
A yeast two-hybrid approach was used to discern possible new effectors for the betagamma subunit of heterotrimeric G proteins. Three of the clones isolated are structurally similar to Gbeta, each exhibiting the WD40 repeat motif. Two of these proteins, the receptor for activated C kinase 1 (RACK1) and the dynein intermediate chain, co-immunoprecipitate with Gbetagamma using an anti-Gbeta antibody. The ... [more]
Throughput
- High Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| GNB1 GNB2L1 | Co-fractionation Co-fractionation Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex. | High | 0.727 | BioGRID | 2664803 |
Curated By
- BioGRID