BAIT
TNFRSF1A
CD120a, FPF, MS5, TBP1, TNF-R, TNF-R-I, TNF-R55, TNFAR, TNFR1, TNFR1-d2, TNFR55, TNFR60, p55, p55-R, p60
tumor necrosis factor receptor superfamily, member 1A
GO Process (11)
GO Function (2)
GO Component (7)
Gene Ontology Biological Process
- apoptotic process [TAS]
- apoptotic signaling pathway [TAS]
- cellular response to mechanical stimulus [IEP]
- cytokine-mediated signaling pathway [ISS]
- extrinsic apoptotic signaling pathway via death domain receptors [TAS]
- inflammatory response [ISS]
- negative regulation of inflammatory response [IMP]
- positive regulation of I-kappaB kinase/NF-kappaB signaling [IEP]
- positive regulation of inflammatory response [ISS]
- positive regulation of transcription from RNA polymerase II promoter [IMP, ISS]
- positive regulation of tyrosine phosphorylation of Stat1 protein [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
DAB2IP
AF9Q34, AIP-1, AIP1, DIP1/2, RP11-298A17.1
DAB2 interacting protein
GO Process (65)
GO Function (20)
GO Component (11)
Gene Ontology Biological Process
- I-kappaB phosphorylation [ISS]
- activation of JUN kinase activity [IDA]
- activation of MAPKKK activity [IDA]
- cell motility involved in cerebral cortex radial glia guided migration [ISS]
- cellular protein catabolic process [IDA]
- cellular response to epidermal growth factor stimulus [ISS]
- cellular response to interleukin-1 [IDA]
- cellular response to lipopolysaccharide [IDA]
- cellular response to tumor necrosis factor [IDA]
- cellular response to vascular endothelial growth factor stimulus [IDA, ISS]
- endothelial cell apoptotic process [TAS]
- extrinsic apoptotic signaling pathway via death domain receptors [IMP]
- intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [ISS]
- layer formation in cerebral cortex [ISS]
- negative regulation of ERK1 and ERK2 cascade [IDA]
- negative regulation of G0 to G1 transition [IDA]
- negative regulation of GTPase activity [ISS]
- negative regulation of I-kappaB kinase/NF-kappaB signaling [IDA]
- negative regulation of MAP kinase activity [IDA, IMP]
- negative regulation of NF-kappaB transcription factor activity [IMP]
- negative regulation of Ras GTPase activity [IMP]
- negative regulation of Ras protein signal transduction [IBA, IC]
- negative regulation of angiogenesis [IDA]
- negative regulation of canonical Wnt signaling pathway [IMP]
- negative regulation of catenin import into nucleus [ISS]
- negative regulation of cell proliferation [IDA]
- negative regulation of cyclin catabolic process [IDA]
- negative regulation of endothelial cell migration [IMP]
- negative regulation of epidermal growth factor receptor signaling pathway [ISS]
- negative regulation of epithelial cell migration [IMP, TAS]
- negative regulation of epithelial cell proliferation [IMP]
- negative regulation of epithelial to mesenchymal transition [IDA, IMP]
- negative regulation of fibroblast proliferation [ISS]
- negative regulation of phosphatidylinositol 3-kinase activity [IDA]
- negative regulation of phosphatidylinositol 3-kinase signaling [IDA]
- negative regulation of protein phosphorylation [IMP, ISS]
- negative regulation of protein serine/threonine kinase activity [IDA, IMP]
- negative regulation of toll-like receptor 4 signaling pathway [IDA]
- negative regulation of transcription from RNA polymerase II promoter [IDA, IMP]
- negative regulation of transcription, DNA-templated [IMP]
- negative regulation of vascular endothelial growth factor receptor signaling pathway [IMP]
- negative regulation of vascular endothelial growth factor signaling pathway [ISS]
- neuron projection morphogenesis [ISS]
- positive regulation of JNK cascade [IDA]
- positive regulation of JUN kinase activity [IDA]
- positive regulation of MAPK cascade [IDA]
- positive regulation of Ras GTPase activity [IBA]
- positive regulation of apoptotic process [IDA]
- positive regulation of apoptotic signaling pathway [IDA]
- positive regulation of cell cycle arrest [IDA]
- positive regulation of dendrite development [ISS]
- positive regulation of neuron migration [ISS]
- positive regulation of neuron projection development [ISS]
- positive regulation of proteasomal protein catabolic process [IMP]
- positive regulation of protein catabolic process [ISS]
- positive regulation of protein serine/threonine kinase activity [IDA, IMP]
- positive regulation of synapse maturation [ISS]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- regulation of ARF GTPase activity [ISS]
- regulation of I-kappaB kinase/NF-kappaB signaling [ISS]
- regulation of p38MAPK cascade [ISS]
- regulation of protein complex assembly [IDA]
- transformed cell apoptotic process [TAS]
- tube formation [IMP]
- vascular endothelial growth factor receptor-2 signaling pathway [ISS]
Gene Ontology Molecular Function- 14-3-3 protein binding [IDA]
- Ras GTPase activator activity [IBA, ISS]
- SH3 domain binding [IDA]
- Toll-like receptor 4 binding [IDA]
- death receptor binding [IPI]
- identical protein binding [IPI]
- kinase binding [IPI]
- mitogen-activated protein kinase kinase binding [IPI]
- mitogen-activated protein kinase kinase kinase binding [IPI]
- phosphatidylinositol 3-kinase binding [IDA]
- phosphatidylinositol 3-kinase regulatory subunit binding [IDA]
- phosphatidylinositol-3-phosphate binding [IDA]
- phosphatidylinositol-4-phosphate binding [IDA]
- protein binding [IPI]
- protein complex binding [IDA]
- protein homodimerization activity [IPI]
- protein kinase binding [IPI]
- protein phosphatase 2A binding [IDA]
- signaling adaptor activity [IDA]
- vascular endothelial growth factor receptor 2 binding [IPI]
- 14-3-3 protein binding [IDA]
- Ras GTPase activator activity [IBA, ISS]
- SH3 domain binding [IDA]
- Toll-like receptor 4 binding [IDA]
- death receptor binding [IPI]
- identical protein binding [IPI]
- kinase binding [IPI]
- mitogen-activated protein kinase kinase binding [IPI]
- mitogen-activated protein kinase kinase kinase binding [IPI]
- phosphatidylinositol 3-kinase binding [IDA]
- phosphatidylinositol 3-kinase regulatory subunit binding [IDA]
- phosphatidylinositol-3-phosphate binding [IDA]
- phosphatidylinositol-4-phosphate binding [IDA]
- protein binding [IPI]
- protein complex binding [IDA]
- protein homodimerization activity [IPI]
- protein kinase binding [IPI]
- protein phosphatase 2A binding [IDA]
- signaling adaptor activity [IDA]
- vascular endothelial growth factor receptor 2 binding [IPI]
Gene Ontology Cellular Component
- axon [ISS]
- cerebellar mossy fiber [ISS]
- climbing fiber [ISS]
- cytoplasm [IDA]
- endocytic vesicle [IDA]
- extracellular vesicular exosome [IDA]
- intrinsic component of the cytoplasmic side of the plasma membrane [IBA]
- neuronal cell body [ISS]
- neuronal cell body membrane [ISS]
- parallel fiber [ISS]
- plasma membrane [IDA]
Homo sapiens
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
AIP1/DAB2IP, a novel member of the Ras-GAP family, transduces TRAF2-induced ASK1-JNK activation.
Previously we have shown that ASK-interacting protein 1 (AIP1, also known as DAB2IP), a novel member of the Ras-GAP protein family, mediates TNF-induced activation of ASK1-JNK signaling pathway. However, the mechanism by which TNF signaling is coupled to AIP1 is not known. Here we show that AIP1 is localized on the plasma membrane in resting endothelial cells (EC) in a ... [more]
J. Biol. Chem. Oct. 22, 2004; 279(43);44955-65 [Pubmed: 15310755]
Throughput
- Low Throughput
Curated By
- BioGRID