BAIT
RIPK1
RIP, RIP1
receptor (TNFRSF)-interacting serine-threonine kinase 1
GO Process (42)
GO Function (8)
GO Component (6)
Gene Ontology Biological Process
- MyD88-independent toll-like receptor signaling pathway [TAS]
- T cell apoptotic process [ISS]
- TRIF-dependent toll-like receptor signaling pathway [TAS]
- activation of JUN kinase activity [TAS]
- activation of cysteine-type endopeptidase activity involved in apoptotic process [TAS]
- amyloid fibril formation [IMP]
- apoptotic process [IMP, TAS]
- apoptotic signaling pathway [TAS]
- cellular protein catabolic process [IDA]
- cellular response to tumor necrosis factor [IDA]
- extrinsic apoptotic signaling pathway [IDA, IMP]
- innate immune response [TAS]
- necroptotic process [IMP]
- necroptotic signaling pathway [IMP, ISS]
- negative regulation of I-kappaB kinase/NF-kappaB signaling [IMP]
- negative regulation of extrinsic apoptotic signaling pathway [IMP]
- peptidyl-serine autophosphorylation [IDA]
- positive regulation of I-kappaB kinase/NF-kappaB signaling [IDA, IEP]
- positive regulation of JNK cascade [IDA]
- positive regulation of NF-kappaB transcription factor activity [IMP]
- positive regulation of apoptotic process [IDA, IMP]
- positive regulation of extrinsic apoptotic signaling pathway [IMP]
- positive regulation of interleukin-8 production [IDA]
- positive regulation of macrophage differentiation [IMP]
- positive regulation of necroptotic process [IMP]
- positive regulation of programmed cell death [IMP]
- positive regulation of protein phosphorylation [IMP]
- positive regulation of reactive oxygen species metabolic process [TAS]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- positive regulation of tumor necrosis factor production [IDA]
- positive regulation of type I interferon production [TAS]
- protein autophosphorylation [IDA]
- protein heterooligomerization [IMP]
- protein homooligomerization [IDA]
- regulation of ATP:ADP antiporter activity [IMP]
- regulation of extrinsic apoptotic signaling pathway in absence of ligand [TAS]
- response to tumor necrosis factor [IMP]
- ripoptosome assembly [IMP]
- toll-like receptor 3 signaling pathway [TAS]
- toll-like receptor 4 signaling pathway [TAS]
- toll-like receptor signaling pathway [TAS]
- tumor necrosis factor-mediated signaling pathway [IC]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
DAB2IP
AF9Q34, AIP-1, AIP1, DIP1/2, RP11-298A17.1
DAB2 interacting protein
GO Process (65)
GO Function (20)
GO Component (11)
Gene Ontology Biological Process
- I-kappaB phosphorylation [ISS]
- activation of JUN kinase activity [IDA]
- activation of MAPKKK activity [IDA]
- cell motility involved in cerebral cortex radial glia guided migration [ISS]
- cellular protein catabolic process [IDA]
- cellular response to epidermal growth factor stimulus [ISS]
- cellular response to interleukin-1 [IDA]
- cellular response to lipopolysaccharide [IDA]
- cellular response to tumor necrosis factor [IDA]
- cellular response to vascular endothelial growth factor stimulus [IDA, ISS]
- endothelial cell apoptotic process [TAS]
- extrinsic apoptotic signaling pathway via death domain receptors [IMP]
- intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [ISS]
- layer formation in cerebral cortex [ISS]
- negative regulation of ERK1 and ERK2 cascade [IDA]
- negative regulation of G0 to G1 transition [IDA]
- negative regulation of GTPase activity [ISS]
- negative regulation of I-kappaB kinase/NF-kappaB signaling [IDA]
- negative regulation of MAP kinase activity [IDA, IMP]
- negative regulation of NF-kappaB transcription factor activity [IMP]
- negative regulation of Ras GTPase activity [IMP]
- negative regulation of Ras protein signal transduction [IBA, IC]
- negative regulation of angiogenesis [IDA]
- negative regulation of canonical Wnt signaling pathway [IMP]
- negative regulation of catenin import into nucleus [ISS]
- negative regulation of cell proliferation [IDA]
- negative regulation of cyclin catabolic process [IDA]
- negative regulation of endothelial cell migration [IMP]
- negative regulation of epidermal growth factor receptor signaling pathway [ISS]
- negative regulation of epithelial cell migration [IMP, TAS]
- negative regulation of epithelial cell proliferation [IMP]
- negative regulation of epithelial to mesenchymal transition [IDA, IMP]
- negative regulation of fibroblast proliferation [ISS]
- negative regulation of phosphatidylinositol 3-kinase activity [IDA]
- negative regulation of phosphatidylinositol 3-kinase signaling [IDA]
- negative regulation of protein phosphorylation [IMP, ISS]
- negative regulation of protein serine/threonine kinase activity [IDA, IMP]
- negative regulation of toll-like receptor 4 signaling pathway [IDA]
- negative regulation of transcription from RNA polymerase II promoter [IDA, IMP]
- negative regulation of transcription, DNA-templated [IMP]
- negative regulation of vascular endothelial growth factor receptor signaling pathway [IMP]
- negative regulation of vascular endothelial growth factor signaling pathway [ISS]
- neuron projection morphogenesis [ISS]
- positive regulation of JNK cascade [IDA]
- positive regulation of JUN kinase activity [IDA]
- positive regulation of MAPK cascade [IDA]
- positive regulation of Ras GTPase activity [IBA]
- positive regulation of apoptotic process [IDA]
- positive regulation of apoptotic signaling pathway [IDA]
- positive regulation of cell cycle arrest [IDA]
- positive regulation of dendrite development [ISS]
- positive regulation of neuron migration [ISS]
- positive regulation of neuron projection development [ISS]
- positive regulation of proteasomal protein catabolic process [IMP]
- positive regulation of protein catabolic process [ISS]
- positive regulation of protein serine/threonine kinase activity [IDA, IMP]
- positive regulation of synapse maturation [ISS]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- regulation of ARF GTPase activity [ISS]
- regulation of I-kappaB kinase/NF-kappaB signaling [ISS]
- regulation of p38MAPK cascade [ISS]
- regulation of protein complex assembly [IDA]
- transformed cell apoptotic process [TAS]
- tube formation [IMP]
- vascular endothelial growth factor receptor-2 signaling pathway [ISS]
Gene Ontology Molecular Function- 14-3-3 protein binding [IDA]
- Ras GTPase activator activity [IBA, ISS]
- SH3 domain binding [IDA]
- Toll-like receptor 4 binding [IDA]
- death receptor binding [IPI]
- identical protein binding [IPI]
- kinase binding [IPI]
- mitogen-activated protein kinase kinase binding [IPI]
- mitogen-activated protein kinase kinase kinase binding [IPI]
- phosphatidylinositol 3-kinase binding [IDA]
- phosphatidylinositol 3-kinase regulatory subunit binding [IDA]
- phosphatidylinositol-3-phosphate binding [IDA]
- phosphatidylinositol-4-phosphate binding [IDA]
- protein binding [IPI]
- protein complex binding [IDA]
- protein homodimerization activity [IPI]
- protein kinase binding [IPI]
- protein phosphatase 2A binding [IDA]
- signaling adaptor activity [IDA]
- vascular endothelial growth factor receptor 2 binding [IPI]
- 14-3-3 protein binding [IDA]
- Ras GTPase activator activity [IBA, ISS]
- SH3 domain binding [IDA]
- Toll-like receptor 4 binding [IDA]
- death receptor binding [IPI]
- identical protein binding [IPI]
- kinase binding [IPI]
- mitogen-activated protein kinase kinase binding [IPI]
- mitogen-activated protein kinase kinase kinase binding [IPI]
- phosphatidylinositol 3-kinase binding [IDA]
- phosphatidylinositol 3-kinase regulatory subunit binding [IDA]
- phosphatidylinositol-3-phosphate binding [IDA]
- phosphatidylinositol-4-phosphate binding [IDA]
- protein binding [IPI]
- protein complex binding [IDA]
- protein homodimerization activity [IPI]
- protein kinase binding [IPI]
- protein phosphatase 2A binding [IDA]
- signaling adaptor activity [IDA]
- vascular endothelial growth factor receptor 2 binding [IPI]
Gene Ontology Cellular Component
- axon [ISS]
- cerebellar mossy fiber [ISS]
- climbing fiber [ISS]
- cytoplasm [IDA]
- endocytic vesicle [IDA]
- extracellular vesicular exosome [IDA]
- intrinsic component of the cytoplasmic side of the plasma membrane [IBA]
- neuronal cell body [ISS]
- neuronal cell body membrane [ISS]
- parallel fiber [ISS]
- plasma membrane [IDA]
Homo sapiens
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
AIP1/DAB2IP, a novel member of the Ras-GAP family, transduces TRAF2-induced ASK1-JNK activation.
Previously we have shown that ASK-interacting protein 1 (AIP1, also known as DAB2IP), a novel member of the Ras-GAP protein family, mediates TNF-induced activation of ASK1-JNK signaling pathway. However, the mechanism by which TNF signaling is coupled to AIP1 is not known. Here we show that AIP1 is localized on the plasma membrane in resting endothelial cells (EC) in a ... [more]
J. Biol. Chem. Oct. 22, 2004; 279(43);44955-65 [Pubmed: 15310755]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| RIPK1 DAB2IP | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - |
Curated By
- BioGRID