SP100
Gene Ontology Biological Process
- DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator [IDA]
- chromatin remodeling [IBA]
- cytokine-mediated signaling pathway [TAS]
- interferon-gamma-mediated signaling pathway [IC, TAS]
- negative regulation of DNA binding [IDA]
- negative regulation of cellular component movement [IMP]
- negative regulation of endothelial cell migration [IMP]
- negative regulation of nucleic acid-templated transcription [IDA]
- negative regulation of protein export from nucleus [IMP]
- negative regulation of sequence-specific DNA binding transcription factor activity [IDA]
- negative regulation of transcription from RNA polymerase II promoter [IDA]
- negative regulation of transcription, DNA-templated [IDA, IMP]
- negative regulation of viral transcription [IDA]
- positive regulation of sequence-specific DNA binding transcription factor activity [IDA]
- positive regulation of transcription, DNA-templated [IDA, IMP]
- regulation of Fas signaling pathway [IMP]
- regulation of angiogenesis [IMP]
- regulation of extrinsic apoptotic signaling pathway via death domain receptors [IMP]
- response to cytokine [IDA]
- response to interferon-gamma [IDA, IMP]
- response to retinoic acid [IDA]
- response to type I interferon [IDA, IMP]
- retinoic acid receptor signaling pathway [IC]
- telomere maintenance [IMP]
- type I interferon signaling pathway [IC]
Gene Ontology Molecular Function- chromatin binding [IBA]
- chromo shadow domain binding [IPI]
- identical protein binding [IPI]
- kinase binding [IPI]
- protein binding [IPI]
- protein domain specific binding [IPI]
- protein homodimerization activity [IPI]
- transcription coactivator activity [IDA]
- transcription corepressor activity [IDA]
- transcription factor binding [IPI]
- chromatin binding [IBA]
- chromo shadow domain binding [IPI]
- identical protein binding [IPI]
- kinase binding [IPI]
- protein binding [IPI]
- protein domain specific binding [IPI]
- protein homodimerization activity [IPI]
- transcription coactivator activity [IDA]
- transcription corepressor activity [IDA]
- transcription factor binding [IPI]
Gene Ontology Cellular Component
ETS1
Gene Ontology Biological Process
- PML body organization [IDA]
- cell motility [IMP]
- immune response [TAS]
- negative regulation of cell cycle [IDA, IMP]
- negative regulation of cell proliferation [TAS]
- positive regulation of cellular component movement [IMP]
- positive regulation of endothelial cell migration [IMP]
- positive regulation of erythrocyte differentiation [IDA]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- positive regulation of transcription, DNA-templated [IDA]
- regulation of angiogenesis [IMP]
- regulation of apoptotic process [IDA]
- response to antibiotic [IDA]
- transcription from RNA polymerase II promoter [IBA, IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
SP100 expression modulates ETS1 transcriptional activity and inhibits cell invasion.
The ETS1 transcription factor is a member of the Ets family of conserved sequence-specific DNA-binding proteins. ETS1 has been shown to play important roles in various cellular processes such as proliferation, differentiation, lymphoid development, motility, invasion and angiogenesis. These diverse roles of ETS1 are likely to be dependent on specific protein interactions. To identify proteins that interact with ETS1, a ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| ETS1 SP100 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - |
Curated By
- BioGRID