TTC3
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
CIT
Gene Ontology Biological Process
- G2/M transition of mitotic cell cycle [IMP, NAS]
- Golgi organization [IMP]
- dendrite development [ISO]
- generation of neurons [ISO]
- metaphase/anaphase transition of mitotic cell cycle [ISO]
- mitotic nuclear division [ISO]
- mitotic sister chromatid segregation [ISO]
- negative regulation of dendrite morphogenesis [ISO]
- phosphorylation [TAS]
- positive regulation of cytokinesis [ISO]
- protein phosphorylation [ISO]
- regulation of actin polymerization or depolymerization [IDA]
- regulation of cell cycle [NAS]
- spermatogenesis [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
The Down syndrome critical region protein TTC3 inhibits neuronal differentiation via RhoA and Citron kinase.
The Down syndrome critical region (DSCR) on Chromosome 21 contains many genes whose duplication may lead to the major phenotypic features of Down syndrome and especially the associated mental retardation. However, the functions of DSCR genes are mostly unknown and their possible involvement in key brain developmental events still largely unexplored. In this report we show that the protein TTC3, ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID