BAIT
IRAK1
IRAK, pelle
interleukin-1 receptor-associated kinase 1
GO Process (37)
GO Function (8)
GO Component (7)
Gene Ontology Biological Process
- JNK cascade [TAS]
- MyD88-dependent toll-like receptor signaling pathway [TAS]
- MyD88-independent toll-like receptor signaling pathway [TAS]
- TRIF-dependent toll-like receptor signaling pathway [TAS]
- activation of MAPK activity [TAS]
- activation of NF-kappaB-inducing kinase activity [IDA]
- innate immune response [TAS]
- interleukin-1-mediated signaling pathway [IMP]
- lipopolysaccharide-mediated signaling pathway [IMP]
- negative regulation of NF-kappaB transcription factor activity [IMP]
- negative regulation of apoptotic process [TAS]
- neurotrophin TRK receptor signaling pathway [TAS]
- nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway [TAS]
- nucleotide-binding oligomerization domain containing signaling pathway [TAS]
- positive regulation of I-kappaB kinase/NF-kappaB signaling [IMP, TAS]
- positive regulation of MAP kinase activity [IBA]
- positive regulation of NF-kappaB transcription factor activity [IDA, TAS]
- positive regulation of transcription, DNA-templated [NAS]
- protein autophosphorylation [IDA, NAS]
- protein oligomerization [IMP]
- protein phosphorylation [TAS]
- protein ubiquitination [TAS]
- regulation of cytokine-mediated signaling pathway [IMP]
- response to interleukin-1 [IMP]
- response to lipopolysaccharide [IMP]
- signal transduction [NAS]
- stress-activated MAPK cascade [TAS]
- toll-like receptor 10 signaling pathway [TAS]
- toll-like receptor 2 signaling pathway [IMP, TAS]
- toll-like receptor 3 signaling pathway [TAS]
- toll-like receptor 4 signaling pathway [IBA, TAS]
- toll-like receptor 5 signaling pathway [TAS]
- toll-like receptor 9 signaling pathway [TAS]
- toll-like receptor TLR1:TLR2 signaling pathway [TAS]
- toll-like receptor TLR6:TLR2 signaling pathway [TAS]
- toll-like receptor signaling pathway [TAS]
- transmembrane receptor protein serine/threonine kinase signaling pathway [NAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
PRKCD
ALPS3, CVID9, MAY1, PKCD, nPKC-delta
protein kinase C, delta
GO Process (41)
GO Function (7)
GO Component (7)
Gene Ontology Biological Process
- Fc-gamma receptor signaling pathway involved in phagocytosis [TAS]
- RNA metabolic process [TAS]
- activation of phospholipase C activity [TAS]
- apoptotic process [IDA, TAS]
- blood coagulation [TAS]
- cellular component disassembly involved in execution phase of apoptosis [TAS]
- cellular senescence [IMP]
- cytokine-mediated signaling pathway [TAS]
- defense response to bacterium [ISS]
- epidermal growth factor receptor signaling pathway [TAS]
- fibroblast growth factor receptor signaling pathway [TAS]
- gene expression [TAS]
- innate immune response [TAS]
- interferon-gamma-mediated signaling pathway [TAS]
- intrinsic apoptotic signaling pathway in response to oxidative stress [TAS]
- mRNA metabolic process [TAS]
- negative regulation of MAP kinase activity [IMP]
- negative regulation of actin filament polymerization [ISS]
- negative regulation of filopodium assembly [ISS]
- negative regulation of glial cell apoptotic process [IMP]
- negative regulation of inflammatory response [IC]
- negative regulation of insulin receptor signaling pathway [ISS, TAS]
- negative regulation of peptidyl-tyrosine phosphorylation [ISS]
- negative regulation of platelet aggregation [ISS]
- negative regulation of protein binding [TAS]
- neurotrophin TRK receptor signaling pathway [TAS]
- neutrophil activation [IDA]
- peptidyl-threonine phosphorylation [IDA]
- platelet activation [TAS]
- positive regulation of ceramide biosynthetic process [IMP]
- positive regulation of glucosylceramide catabolic process [IMP]
- positive regulation of phospholipid scramblase activity [IMP]
- positive regulation of protein dephosphorylation [IMP]
- positive regulation of response to DNA damage stimulus [IMP]
- positive regulation of sphingomyelin catabolic process [IMP]
- positive regulation of superoxide anion generation [IMP]
- protein phosphorylation [IDA]
- protein stabilization [NAS]
- regulation of receptor activity [TAS]
- signal transduction [TAS]
- termination of signal transduction [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
IL-1R-associated kinase-1 mediates protein kinase Cδ-induced IL-1β production in monocytes.
The role of IL-1R-associated kinase (IRAK)1 and its interaction with protein kinase C (PKC)δ in monocytes to regulate IL-1β production has not been reported so far. The present study thus investigates such mechanisms in the THP1 cell line and human monocytes. PMA treatment to THP1 cells induced CD11b, TLR2, TLR4, CD36, IRAK1, IRAK3, and IRAK4 expression, IRAK1 kinase activity, PKCδ ... [more]
J. Immunol. Sep. 01, 2011; 187(5);2632-45 [Pubmed: 21804018]
Throughput
- Low Throughput
Curated By
- BioGRID