BAIT
RELA
p65
v-rel reticuloendotheliosis viral oncogene homolog A (avian)
GO Process (41)
GO Function (25)
GO Component (8)
Gene Ontology Biological Process
- NIK/NF-kappaB signaling [IBA]
- cellular response to hydrogen peroxide [ISO]
- cellular response to interleukin-1 [ISO]
- cellular response to interleukin-6 [ISO]
- cellular response to nicotine [ISO]
- cellular response to peptide hormone stimulus [ISO]
- cellular response to stress [IBA]
- cellular response to tumor necrosis factor [ISO]
- cytokine-mediated signaling pathway [ISO]
- defense response [IMP]
- hair follicle development [IMP]
- inflammatory response [ISO]
- innate immune response [IBA]
- liver development [IMP]
- negative regulation of apoptotic process [IDA, ISO]
- negative regulation of extrinsic apoptotic signaling pathway [IDA, ISO]
- negative regulation of insulin receptor signaling pathway [ISO]
- negative regulation of protein catabolic process [IMP]
- negative regulation of transcription from RNA polymerase II promoter [IBA, ISO]
- negative regulation of transcription, DNA-templated [ISO]
- nucleotide-binding oligomerization domain containing 2 signaling pathway [ISO]
- organ morphogenesis [IMP]
- positive regulation of I-kappaB kinase/NF-kappaB signaling [IDA]
- positive regulation of NF-kappaB transcription factor activity [IDA, ISO]
- positive regulation of Schwann cell differentiation [ISO]
- positive regulation of cell proliferation [ISO]
- positive regulation of chondrocyte differentiation [ISO]
- positive regulation of interleukin-12 biosynthetic process [IDA]
- positive regulation of miRNA metabolic process [ISO]
- positive regulation of transcription from RNA polymerase II promoter [IBA, ISO]
- positive regulation of transcription, DNA-templated [IDA, IMP, ISO, TAS]
- regulation of inflammatory response [IDA]
- regulation of transcription from RNA polymerase II promoter [IDA]
- response to UV-B [ISO]
- response to bacterium [IDA]
- response to cytokine [IBA]
- response to interleukin-1 [ISO]
- response to muramyl dipeptide [IDA]
- response to muscle stretch [IDA]
- response to organic substance [ISO]
- transcription from RNA polymerase II promoter [ISO]
Gene Ontology Molecular Function- DNA binding [IDA, ISO]
- NF-kappaB binding [ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription [ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [ISO]
- RNA polymerase II distal enhancer sequence-specific DNA binding [ISO]
- RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity [IDA, ISO]
- RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [ISO]
- RNA polymerase II regulatory region sequence-specific DNA binding [IDA]
- activating transcription factor binding [ISO]
- ankyrin repeat binding [IPI]
- chromatin binding [IDA, ISO]
- enzyme binding [IPI]
- identical protein binding [ISO]
- phosphate ion binding [ISO]
- protein N-terminus binding [ISO]
- protein binding [IPI]
- protein complex binding [ISO]
- protein kinase binding [IPI, ISO]
- repressing transcription factor binding [ISO]
- sequence-specific DNA binding [IDA, ISO]
- sequence-specific DNA binding transcription factor activity [IDA, ISO]
- transcription factor binding [ISO]
- transcription regulatory region DNA binding [ISO]
- ubiquitin protein ligase binding [ISO]
- DNA binding [IDA, ISO]
- NF-kappaB binding [ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription [ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [ISO]
- RNA polymerase II distal enhancer sequence-specific DNA binding [ISO]
- RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity [IDA, ISO]
- RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [ISO]
- RNA polymerase II regulatory region sequence-specific DNA binding [IDA]
- activating transcription factor binding [ISO]
- ankyrin repeat binding [IPI]
- chromatin binding [IDA, ISO]
- enzyme binding [IPI]
- identical protein binding [ISO]
- phosphate ion binding [ISO]
- protein N-terminus binding [ISO]
- protein binding [IPI]
- protein complex binding [ISO]
- protein kinase binding [IPI, ISO]
- repressing transcription factor binding [ISO]
- sequence-specific DNA binding [IDA, ISO]
- sequence-specific DNA binding transcription factor activity [IDA, ISO]
- transcription factor binding [ISO]
- transcription regulatory region DNA binding [ISO]
- ubiquitin protein ligase binding [ISO]
Gene Ontology Cellular Component
Mus musculus
PREY
NFKB2
NF-kappaB2, lyt, p49, p49/p100, p50B, p52
nuclear factor of kappa light polypeptide gene enhancer in B cells 2, p49/p100
GO Process (15)
GO Function (6)
GO Component (6)
Gene Ontology Biological Process
- I-kappaB kinase/NF-kappaB signaling [IBA]
- NIK/NF-kappaB signaling [IDA]
- cellular response to stress [IBA]
- extracellular matrix organization [IMP]
- follicular dendritic cell differentiation [IMP]
- germinal center formation [IMP]
- inflammatory response [IBA]
- innate immune response [IBA]
- lymph node development [TAS]
- negative regulation of transcription from RNA polymerase II promoter [IBA]
- positive regulation of transcription from RNA polymerase II promoter [IBA, ISO]
- regulation of transcription, DNA-templated [ISO]
- response to cytokine [IBA]
- spleen development [IMP]
- transcription from RNA polymerase II promoter [ISO]
Gene Ontology Molecular Function- RNA polymerase II core promoter proximal region sequence-specific DNA binding [ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [ISO]
- RNA polymerase II regulatory region sequence-specific DNA binding [IBA]
- chromatin binding [IBA]
- protein binding [IPI]
- sequence-specific DNA binding RNA polymerase II transcription factor activity [IBA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [ISO]
- RNA polymerase II regulatory region sequence-specific DNA binding [IBA]
- chromatin binding [IBA]
- protein binding [IPI]
- sequence-specific DNA binding RNA polymerase II transcription factor activity [IBA]
Gene Ontology Cellular Component
Mus musculus
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
The role of TRAF2 binding to the type I interferon receptor in alternative NF kappaB activation and antiviral response.
Type I interferons (IFNs) play critical roles in the host defense by modulating gene expression through the IFN-dependent activation of STAT and NFkappaB transcription factors. Previous studies established that IFN activates NFkappaB through a classical NFkappaB pathway that results in IkappaBalpha degradation and formation of p50-containing NFkappaB complexes, as well as an alternative pathway that involves NFkappaB-inducing kinase and TRAF2, ... [more]
J. Biol. Chem. May. 23, 2008; 283(21);14309-16 [Pubmed: 18362156]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| NFKB2 RELA | Two-hybrid Two-hybrid Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation. | High | - | BioGRID | - |
Curated By
- BioGRID