BAIT
UBQLN4
A1U, A1Up, C1orf6, CIP75, UBIN, RP11-336K24.8
ubiquilin 4
GO Process (1)
GO Function (3)
GO Component (6)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
PIN1
DOD, UBL5
peptidylprolyl cis/trans isomerase, NIMA-interacting 1
GO Process (13)
GO Function (6)
GO Component (3)
Gene Ontology Biological Process
- cytokine-mediated signaling pathway [TAS]
- innate immune response [TAS]
- negative regulation of ERK1 and ERK2 cascade [IDA]
- negative regulation of cell motility [IDA]
- negative regulation of transforming growth factor beta receptor signaling pathway [IDA]
- negative regulation of type I interferon production [TAS]
- positive regulation of Rho GTPase activity [IMP]
- positive regulation of protein phosphorylation [IGI]
- positive regulation of ubiquitin-protein transferase activity [IDA]
- protein peptidyl-prolyl isomerization [IDA]
- regulation of cytokinesis [IGI, IMP]
- regulation of mitosis [TAS]
- regulation of pathway-restricted SMAD protein phosphorylation [IDA]
Gene Ontology Molecular Function
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration.
Many human inherited neurodegenerative disorders are characterized by loss of balance due to cerebellar Purkinje cell (PC) degeneration. Although the disease-causing mutations have been identified for a number of these disorders, the normal functions of the proteins involved remain, in many cases, unknown. To gain insight into the function of proteins involved in PC degeneration, we developed an interaction network ... [more]
Cell May. 19, 2006; 125(4);801-14 [Pubmed: 16713569]
Throughput
- High Throughput
Curated By
- BioGRID