ATXN1
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
OTX2
Gene Ontology Biological Process
- axon guidance [IDA]
- forebrain development [TAS]
- midbrain development [TAS]
- positive regulation of embryonic development [ISS]
- positive regulation of gastrulation [ISS]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- positive regulation of transcription, DNA-templated [ISS]
- primitive streak formation [ISS]
- protein complex assembly [IDA]
- regulation of fibroblast growth factor receptor signaling pathway [TAS]
- regulation of smoothened signaling pathway [TAS]
Gene Ontology Molecular Function- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- eukaryotic initiation factor 4E binding [TAS]
- protein binding [IPI]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- eukaryotic initiation factor 4E binding [TAS]
- protein binding [IPI]
Gene Ontology Cellular Component
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration.
Many human inherited neurodegenerative disorders are characterized by loss of balance due to cerebellar Purkinje cell (PC) degeneration. Although the disease-causing mutations have been identified for a number of these disorders, the normal functions of the proteins involved remain, in many cases, unknown. To gain insight into the function of proteins involved in PC degeneration, we developed an interaction network ... [more]
Throughput
- High Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| ATXN1 OTX2 | Two-hybrid Two-hybrid Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation. | High | - | BioGRID | 823869 |
Curated By
- BioGRID