BAIT
APTX
AOA, AOA1, AXA1, EAOH, EOAHA, FHA-HIT, RP11-562M8.1
aprataxin
GO Process (8)
GO Function (10)
GO Component (5)
Gene Ontology Biological Process
Gene Ontology Molecular Function- DNA 5'-adenosine monophosphate hydrolase activity [IDA]
- chromatin binding [IDA]
- damaged DNA binding [IDA]
- double-stranded DNA binding [IDA]
- double-stranded RNA binding [IDA]
- phosphoglycolate phosphatase activity [IDA]
- phosphoprotein binding [IPI]
- polynucleotide 3'-phosphatase activity [IDA]
- protein N-terminus binding [IPI]
- protein binding [IPI]
- DNA 5'-adenosine monophosphate hydrolase activity [IDA]
- chromatin binding [IDA]
- damaged DNA binding [IDA]
- double-stranded DNA binding [IDA]
- double-stranded RNA binding [IDA]
- phosphoglycolate phosphatase activity [IDA]
- phosphoprotein binding [IPI]
- polynucleotide 3'-phosphatase activity [IDA]
- protein N-terminus binding [IPI]
- protein binding [IPI]
Gene Ontology Cellular Component
Homo sapiens
PREY
PICK1
PICK, PRKCABP, RP5-1039K5.11-004
protein interacting with PRKCA 1
GO Process (18)
GO Function (11)
GO Component (8)
Gene Ontology Biological Process
- ATP catabolic process [ISS]
- DNA methylation involved in embryo development [NAS]
- DNA methylation involved in gamete generation [TAS]
- cellular response to decreased oxygen levels [ISS]
- cellular response to glucose starvation [ISS]
- dendritic spine maintenance [ISS]
- dendritic spine organization [ISS]
- glial cell development [ISS]
- long term synaptic depression [ISS]
- monoamine transport [IDA]
- negative regulation of Arp2/3 complex-mediated actin nucleation [ISS]
- neuronal ion channel clustering [TAS]
- positive regulation of receptor internalization [ISS]
- protein kinase C-activating G-protein coupled receptor signaling pathway [IDA]
- protein phosphorylation [ISS]
- receptor clustering [ISS]
- retrograde vesicle-mediated transport, Golgi to ER [NAS]
- synaptic transmission [TAS]
Gene Ontology Molecular Function- ATPase activity [ISS]
- Arp2/3 complex binding [ISS]
- G-protein coupled receptor binding [ISS]
- actin filament binding [ISS]
- enzyme binding [IPI]
- identical protein binding [ISS]
- protein C-terminus binding [IPI]
- protein binding [IPI]
- protein domain specific binding [ISS]
- protein kinase C binding [ISS]
- receptor binding [ISS]
- ATPase activity [ISS]
- Arp2/3 complex binding [ISS]
- G-protein coupled receptor binding [ISS]
- actin filament binding [ISS]
- enzyme binding [IPI]
- identical protein binding [ISS]
- protein C-terminus binding [IPI]
- protein binding [IPI]
- protein domain specific binding [ISS]
- protein kinase C binding [ISS]
- receptor binding [ISS]
Gene Ontology Cellular Component
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration.
Many human inherited neurodegenerative disorders are characterized by loss of balance due to cerebellar Purkinje cell (PC) degeneration. Although the disease-causing mutations have been identified for a number of these disorders, the normal functions of the proteins involved remain, in many cases, unknown. To gain insight into the function of proteins involved in PC degeneration, we developed an interaction network ... [more]
Cell May. 19, 2006; 125(4);801-14 [Pubmed: 16713569]
Throughput
- High Throughput
Curated By
- BioGRID