BAIT

GFI1B

BDPLT17, RP11-415H23.1

growth factor independent 1B transcription repressor

GO Process (3)

GO Function (2)

GO Component (3)

Gene Ontology Biological Process

cell proliferation [TAS]

negative regulation of transcription from RNA polymerase II promoter [TAS]

transcription from RNA polymerase II promoter [TAS]

Gene Ontology Molecular Function

RNA polymerase II transcription factor binding [IPI]
protein binding [IPI]

Gene Ontology Cellular Component

nuclear matrix [IDA]

transcription factor complex [IDA]

CRISPR Database OMIM HGNC Alliance of Genome Resources Entrez Gene RefSeq UniprotKB Ensembl

Homo sapiens

PREY

NSMF

HH9, NELF, RP11-48C7.1

NMDA receptor synaptonuclear signaling and neuronal migration factor

GO Process (8)

GO Function (1)

GO Component (15)

Gene Ontology Biological Process

cellular response to amino acid stimulus [ISS]

cellular response to electrical stimulus [ISS]

cellular response to gonadotropin stimulus [ISS]

positive regulation of neuron migration [IMP]

positive regulation of protein dephosphorylation [ISS]

regulation of dendrite morphogenesis [ISS]

regulation of neuron apoptotic process [ISS]

regulation of neuronal synaptic plasticity [ISS]

Gene Ontology Molecular Function

calcium-dependent protein binding [ISS]

Gene Ontology Cellular Component

apical dendrite [ISS]

cortical cytoskeleton [ISS]

cytoplasm [IDA]

neuron projection [ISS]

nuclear envelope [ISS]

nuclear euchromatin [ISS]

nuclear matrix [ISS]

nuclear membrane [ISS]

nucleoplasm [IDA]

perikaryon [ISS]

postsynaptic density [ISS]

CRISPR Database OMIM HGNC Alliance of Genome Resources Entrez Gene RefSeq UniprotKB Ensembl

Homo sapiens

Two-hybrid

Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.

Publication

A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration.

Lim J, Hao T, Shaw C, Patel AJ, Szabo G, Rual JF, Fisk CJ, Li N, Smolyar A, Hill DE, Barabasi AL, Vidal M, Zoghbi HY

Many human inherited neurodegenerative disorders are characterized by loss of balance due to cerebellar Purkinje cell (PC) degeneration. Although the disease-causing mutations have been identified for a number of these disorders, the normal functions of the proteins involved remain, in many cases, unknown. To gain insight into the function of proteins involved in PC degeneration, we developed an interaction network ... [more]

Cell May. 19, 2006; 125(4);801-14 [Pubmed: 16713569]

Throughput

High Throughput

Curated By

BioGRID