Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.

Publication

A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration.

Lim J, Hao T, Shaw C, Patel AJ, Szabo G, Rual JF, Fisk CJ, Li N, Smolyar A, Hill DE, Barabasi AL, Vidal M, Zoghbi HY

Many human inherited neurodegenerative disorders are characterized by loss of balance due to cerebellar Purkinje cell (PC) degeneration. Although the disease-causing mutations have been identified for a number of these disorders, the normal functions of the proteins involved remain, in many cases, unknown. To gain insight into the function of proteins involved in PC degeneration, we developed an interaction network ... [more]

Cell May. 19, 2006; 125(4);801-14 [Pubmed: 16713569]

Throughput

High Throughput

Related interactions

Interaction	Experimental Evidence Code	Dataset	Throughput	Score	Curated By	Notes
USP7 MAGEE1	Protein-peptide Protein-peptide An interaction is detected between a protein and a peptide derived from an interaction partner. This includes phage display experiments.	Benz C (2022)	High	-	BioGRID	-

Curated By

BioGRID

Interaction Summary

USP7

Gene Ontology Biological Process

Gene Ontology Molecular Function

cysteine-type endopeptidase activity [IMP]p53 binding [IDA]protein C-terminus binding [IPI]protein binding [IPI]transcription factor binding [IPI]ubiquitin protein ligase binding [IPI]ubiquitin thiolesterase activity [IDA, IMP]ubiquitin-specific protease activity [IDA, IMP]

Gene Ontology Cellular Component

MAGEE1