MARK1
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
MAP2
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- CA3 pyramidal cell dendrite [ISO]
- cell body [ISO]
- cytoplasm [ISO]
- dendrite [IDA, ISO]
- dendritic shaft [ISO]
- intracellular [ISO]
- neuron projection [IDA, ISO]
- neuronal cell body [IDA, ISO]
- neuronal postsynaptic density [ISO]
- nuclear periphery [ISO]
- nucleolus [ISO]
- postsynaptic density [ISO]
- protein complex [IDA]
- rough endoplasmic reticulum [IDA]
- smooth endoplasmic reticulum [IDA]
Biochemical Activity (Phosphorylation)
An interaction is inferred from the biochemical effect of one protein upon another, for example, GTP-GDP exchange activity or phosphorylation of a substrate by a kinase. The bait protein executes the activity on the substrate hit protein. A Modification value is recorded for interactions of this type with the possible values Phosphorylation, Ubiquitination, Sumoylation, Dephosphorylation, Methylation, Prenylation, Acetylation, Deubiquitination, Proteolytic Processing, Glucosylation, Nedd(Rub1)ylation, Deacetylation, No Modification, Demethylation.
Publication
Phosphorylation of microtubule-associated proteins MAP2 and MAP4 by the protein kinase p110mark. Phosphorylation sites and regulation of microtubule dynamics.
The phosphorylation of microtubule-associated proteins (MAPs) is thought to be a key factor in the regulation of microtubule stability. We have shown recently that a novel protein kinase, termed p110 microtubule-affinity regulating kinase ("MARK"), phosphorylates microtubule-associated protein tau at the KXGS motifs in the region of internal repeats and causes the detachment of tau from microtubules (Drewes, G., Trinczek, B., ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID