MARK2
Gene Ontology Biological Process
- activation of protein kinase activity [TAS]
- establishment of cell polarity [IDA, TAS]
- establishment or maintenance of epithelial cell apical/basal polarity [IDA]
- intracellular signal transduction [IDA]
- mitochondrion degradation [NAS]
- mitochondrion localization [NAS]
- neuron migration [ISS]
- peptidyl-threonine phosphorylation [TAS]
- positive regulation of neuron projection development [IDA]
- protein autophosphorylation [ISS]
- protein phosphorylation [IDA, NAS]
- regulation of axonogenesis [IMP]
- regulation of cytoskeleton organization [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
PPP2R4
Gene Ontology Biological Process
- ATP catabolic process [IDA]
- mitotic spindle organization in nucleus [IBA]
- negative regulation of phosphoprotein phosphatase activity [IDA]
- negative regulation of protein dephosphorylation [IDA]
- positive regulation of apoptotic process [IDA]
- positive regulation of phosphoprotein phosphatase activity [IDA]
- positive regulation of protein dephosphorylation [IDA]
- protein peptidyl-prolyl isomerization [IBA]
- regulation of phosphoprotein phosphatase activity [IDA]
Gene Ontology Molecular Function- ATP binding [IDA]
- ATPase activity [IDA]
- peptidyl-prolyl cis-trans isomerase activity [IBA]
- protein heterodimerization activity [TAS]
- protein homodimerization activity [IDA]
- protein phosphatase 2A binding [IDA]
- protein phosphatase type 2A regulator activity [IDA, TAS]
- protein tyrosine phosphatase activator activity [IDA]
- receptor binding [IPI]
- ATP binding [IDA]
- ATPase activity [IDA]
- peptidyl-prolyl cis-trans isomerase activity [IBA]
- protein heterodimerization activity [TAS]
- protein homodimerization activity [IDA]
- protein phosphatase 2A binding [IDA]
- protein phosphatase type 2A regulator activity [IDA, TAS]
- protein tyrosine phosphatase activator activity [IDA]
- receptor binding [IPI]
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
aPKC acts upstream of PAR-1b in both the establishment and maintenance of mammalian epithelial polarity.
aPKC and PAR-1 are required for cell polarity in various contexts. In mammalian epithelial cells, aPKC localizes at tight junctions (TJs) and plays an indispensable role in the development of asymmetric intercellular junctions essential for the establishment and maintenance of apicobasal polarity. On the other hand, one of the mammalian PAR-1 kinases, PAR-1b/EMK1/MARK2, localizes to the lateral membrane in a ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID