BAIT
ADCY5
AC5, FDFM
adenylate cyclase 5
GO Process (15)
GO Function (2)
GO Component (2)
Gene Ontology Biological Process
- activation of phospholipase C activity [TAS]
- activation of protein kinase A activity [TAS]
- adenylate cyclase-activating G-protein coupled receptor signaling pathway [TAS]
- adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway [TAS]
- cellular response to glucagon stimulus [TAS]
- energy reserve metabolic process [TAS]
- epidermal growth factor receptor signaling pathway [TAS]
- fibroblast growth factor receptor signaling pathway [TAS]
- innate immune response [TAS]
- neurotrophin TRK receptor signaling pathway [TAS]
- signal transduction [TAS]
- small molecule metabolic process [TAS]
- synaptic transmission [TAS]
- transmembrane transport [TAS]
- water transport [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
GNB1
AA409223, C77571, Gnb-1, RP23-183D11.1
guanine nucleotide binding protein (G protein), beta 1
GO Process (10)
GO Function (6)
GO Component (11)
Gene Ontology Biological Process
- G-protein coupled receptor signaling pathway [IDA, ISO, TAS]
- GTP catabolic process [ISA, ISO]
- cardiac muscle cell apoptotic process [ISO]
- cell proliferation [IDA]
- cellular response to hypoxia [ISO]
- phospholipase C-activating G-protein coupled receptor signaling pathway [IDA]
- phototransduction, visible light [ISA]
- positive regulation of cytosolic calcium ion concentration [ISO]
- retina development in camera-type eye [IMP]
- sensory perception of taste [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Conditional stimulation of type V and VI adenylyl cyclases by G protein betagamma subunits.
In a yeast two-hybrid screen of mouse brain cDNA library, using the N-terminal region of human type V adenylyl cyclase (hACV) as bait, we identified G protein beta2 subunit as an interacting partner. Additional yeast two-hybrid assays showed that the Gbeta(1) subunit also interacts with the N-terminal segments of hACV and human type VI adenylyl cyclase (hACVI). In vitro adenylyl ... [more]
J. Biol. Chem. Jan. 05, 2007; 282(1);294-302 [Pubmed: 17110384]
Throughput
- Low Throughput
Additional Notes
- source of Gbeta1 not clear
Related interactions
Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
---|---|---|---|---|---|---|
ADCY5 GNB1 | Reconstituted Complex Reconstituted Complex An interaction is detected between purified proteins in vitro. | Low | - | BioGRID | 721265 |
Curated By
- BioGRID