BAIT

SLC4A1

AE1, BND3, CD233, DI, EMPB3, EPB3, FR, RTA1A, SW, WD, WD1, WR

solute carrier family 4 (anion exchanger), member 1 (Diego blood group)

GO Process (7)

GO Function (9)

GO Component (8)

Gene Ontology Biological Process

anion transport [IDA]

bicarbonate transport [IDA, TAS]

cellular ion homeostasis [TAS]

chloride transport [ISS]

ion transport [TAS]

small molecule metabolic process [TAS]

transmembrane transport [TAS]

Gene Ontology Molecular Function

anion transmembrane transporter activity [TAS]
anion:anion antiporter activity [IDA]
ankyrin binding [IPI]
bicarbonate transmembrane transporter activity [IDA]
chloride transmembrane transporter activity [ISS]
inorganic anion exchanger activity [IDA, TAS]
protein anchor [TAS]
protein binding [IPI]
protein homodimerization activity [IPI]

Gene Ontology Cellular Component

basolateral plasma membrane [IDA]

blood microparticle [IDA]

cortical cytoskeleton [IDA]

extracellular vesicular exosome [IDA]

integral component of membrane [NAS]

integral component of plasma membrane [IDA]

plasma membrane [TAS]

CRISPR Database HGNC Alliance of Genome Resources OMIM Entrez Gene RefSeq UniprotKB Ensembl

Homo sapiens

PREY

HBA1

HBA-T3, HBH

hemoglobin, alpha 1

GO Process (8)

GO Function (3)

GO Component (9)

Gene Ontology Biological Process

bicarbonate transport [TAS]

hydrogen peroxide catabolic process [IDA]

oxidation-reduction process [IDA]

oxygen transport [TAS]

positive regulation of cell death [IDA]

protein heterooligomerization [IDA]

response to hydrogen peroxide [IDA]

small molecule metabolic process [TAS]

Gene Ontology Molecular Function

haptoglobin binding [IDA]
peroxidase activity [IDA]
protein binding [IPI]

Gene Ontology Cellular Component

blood microparticle [IDA]

cytosolic small ribosomal subunit [IDA]

endocytic vesicle lumen [TAS]

extracellular region [TAS]

extracellular vesicular exosome [IDA]

haptoglobin-hemoglobin complex [IDA]

hemoglobin complex [IDA, TAS]

CRISPR Database OMIM HGNC Alliance of Genome Resources Entrez Gene RefSeq UniprotKB Ensembl

Homo sapiens

Affinity Capture-Western

An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.

Publication

Apolipoprotein J/clusterin in human erythrocytes is involved in the molecular process of defected material disposal during vesiculation.

Antonelou MH, Kriebardis AG, Stamoulis KE, Trougakos IP, Papassideri IS

We have showed that secretory Apolipoprotein J/Clusterin (sCLU) is down-regulated in senescent, stressed or diseased red blood cells (RBCs). It was hypothesized that sCLU loss relates to RBCs vesiculation, a mechanism that removes erythrocyte membrane patches containing defective or potentially harmful components.To investigate this issue we employed a combination of biochemical and microscopical approaches in freshly prepared RBCs or RBCs ... [more]

PLoS ONE Oct. 22, 2011; 6(10);e26033 [Pubmed: 22016805]

Throughput

Low Throughput

Curated By

BioGRID