SORBS2
Gene Ontology Molecular Function
Gene Ontology Cellular Component
VCL
Gene Ontology Biological Process
- adherens junction assembly [ISO]
- apical junction assembly [ISO]
- axon extension [IGI]
- cell adhesion [IDA]
- epithelial cell-cell adhesion [ISO]
- lamellipodium assembly [IDA]
- morphogenesis of an epithelium [ISO]
- platelet aggregation [ISO]
- protein localization to cell surface [ISO]
- regulation of cell migration [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- Z disc [ISO]
- actin filament [ISO]
- adherens junction [IDA]
- cell-cell adherens junction [ISO]
- cell-cell junction [IDA]
- costamere [IDA, ISO]
- cytoplasm [IDA]
- extracellular vesicular exosome [ISO]
- fascia adherens [IDA]
- focal adhesion [IDA, ISO]
- intercalated disc [ISO]
- plasma membrane [IDA]
- protein complex [ISO]
- sarcolemma [ISO]
- stress fiber [ISO]
- vesicle [ISO]
Reconstituted Complex
An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator.
Publication
Arg/Abl-binding protein, a Z-body and Z-band protein, binds sarcomeric, costameric, and signaling molecules.
ArgBP2 (Arg/Abl-Binding Protein) is expressed at high levels in the heart and is localized in the Z-bands of mature myofibrils. ArgBP2 is a member of a small family of proteins that also includes vinexin and CAP (c-Cbl-associated protein), all characterized by having one sorbin homology (SOHO) domain and three C-terminal SH3 domains. Antibodies directed against ArgBP2 also react with the ... [more]
Throughput
- Low Throughput
Additional Notes
- source of ARGBP2 unclear
Curated By
- BioGRID