KCNA5
Gene Ontology Biological Process
- atrial cardiac muscle cell action potential [ISO]
- membrane hyperpolarization [ISO]
- negative regulation of cytosolic calcium ion concentration [IMP]
- negative regulation of potassium ion transport [ISO]
- positive regulation of G1/S transition of mitotic cell cycle [IDA]
- positive regulation of myoblast proliferation [IDA]
- potassium ion export [ISO]
- potassium ion homeostasis [IMP]
- potassium ion transmembrane transport [IBA, ISO]
- potassium ion transport [IMP, ISO]
- protein oligomerization [IMP]
- regulation of atrial cardiac muscle cell membrane repolarization [ISO]
- regulation of heart rate by cardiac conduction [ISO]
- regulation of membrane potential [IMP, ISO]
- regulation of potassium ion transport [ISO]
- regulation of vasoconstriction [ISO]
- response to hydrogen peroxide [IEP]
- response to hyperoxia [IEP]
- response to hypoxia [IEP]
- response to mechanical stimulus [IEP]
- response to organic substance [IEP]
Gene Ontology Molecular Function- alpha-actinin binding [ISO]
- delayed rectifier potassium channel activity [IBA, ISO]
- outward rectifier potassium channel activity [IMP, ISO]
- potassium channel inhibitor activity [ISO]
- protein binding [IPI]
- protein kinase binding [ISO]
- receptor binding [IPI]
- scaffold protein binding [ISO]
- voltage-gated potassium channel activity [ISO]
- voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization [ISO]
- alpha-actinin binding [ISO]
- delayed rectifier potassium channel activity [IBA, ISO]
- outward rectifier potassium channel activity [IMP, ISO]
- potassium channel inhibitor activity [ISO]
- protein binding [IPI]
- protein kinase binding [ISO]
- receptor binding [IPI]
- scaffold protein binding [ISO]
- voltage-gated potassium channel activity [ISO]
- voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization [ISO]
Gene Ontology Cellular Component
- Golgi apparatus [IDA, ISO]
- Z disc [IDA]
- endoplasmic reticulum [IDA]
- integral component of membrane [IBA]
- intercalated disc [IDA, ISO]
- intracellular canaliculus [IDA]
- membrane [ISO]
- membrane raft [ISO]
- perinuclear region of cytoplasm [IDA]
- plasma membrane [IDA, ISO]
- voltage-gated potassium channel complex [ISO]
DCTN2
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Kv1.5 surface expression is modulated by retrograde trafficking of newly endocytosed channels by the dynein motor.
In this article we have investigated the mechanisms by which retrograde trafficking regulates the surface expression of the voltage-gated potassium channel, Kv1.5. Overexpression of p50/dynamitin, known to disrupt the dynein-dynactin complex responsible for carrying vesicle cargo, substantially increased outward K+ currents in HEK293 cells stably expressing Kv1.5 (0.57+/-0.07 nA/pF, n=12; to 1.18+/-0.2 nA/pF, n=12, P<0.01), as did treatment of the ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID