BAIT
AP2A1
ADTAA, AP2-ALPHA, CLAPA1
adaptor-related protein complex 2, alpha 1 subunit
GO Process (13)
GO Function (3)
GO Component (7)
Gene Ontology Biological Process
- Golgi to endosome transport [NAS]
- antigen processing and presentation of exogenous peptide antigen via MHC class II [TAS]
- axon guidance [TAS]
- clathrin-mediated endocytosis [TAS]
- endocytosis [NAS]
- epidermal growth factor receptor signaling pathway [TAS]
- intracellular protein transport [NAS]
- negative regulation of epidermal growth factor receptor signaling pathway [TAS]
- negative regulation of hyaluronan biosynthetic process [IDA, IMP]
- neurotrophin TRK receptor signaling pathway [TAS]
- regulation of defense response to virus by virus [TAS]
- synaptic transmission [TAS]
- viral process [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
EPN1
Epsin 1
GO Process (5)
GO Function (1)
GO Component (2)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Rattus norvegicus
Protein-peptide
An interaction is detected between a protein and a peptide derived from an interaction partner. This includes phage display experiments.
Publication
Accessory protein recruitment motifs in clathrin-mediated endocytosis.
Clathrin-mediated endocytosis depends upon the interaction of accessory proteins with the alpha-ear of the AP-2 adaptor. We present structural characterization of these regulatory interactions. DPF and DPW motif peptides derived from eps15 and epsin bind in type I beta turn conformations to a conserved pocket on the alpha-ear platform. We show evidence for a second binding site that is DPW ... [more]
Structure Jun. 01, 2002; 10(6);797-809 [Pubmed: 12057195]
Throughput
- Low Throughput
Curated By
- BioGRID