SYNJ1
Gene Ontology Biological Process
- inositol phosphate dephosphorylation [ISS]
- inositol phosphate metabolic process [TAS]
- neurotransmitter transport [ISS]
- phosphate-containing compound metabolic process [TAS]
- phosphatidylinositol biosynthetic process [TAS]
- phosphatidylinositol dephosphorylation [ISS]
- phosphatidylinositol metabolic process [ISS]
- phospholipid metabolic process [TAS]
- positive regulation of synaptic vesicle uncoating [TAS]
- regulation of synaptic vesicle membrane organization [TAS]
- small molecule metabolic process [TAS]
- synaptic vesicle endocytosis [ISS]
- synaptic vesicle priming [ISS]
- synaptic vesicle transport [ISS]
- synaptic vesicle uncoating [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
CLTA
Gene Ontology Biological Process
- antigen processing and presentation of exogenous peptide antigen via MHC class II [TAS]
- axon guidance [TAS]
- epidermal growth factor receptor signaling pathway [TAS]
- membrane organization [TAS]
- negative regulation of epidermal growth factor receptor signaling pathway [TAS]
- neurotrophin TRK receptor signaling pathway [TAS]
- post-Golgi vesicle-mediated transport [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Reconstituted Complex
An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator.
Publication
Accessory protein recruitment motifs in clathrin-mediated endocytosis.
Clathrin-mediated endocytosis depends upon the interaction of accessory proteins with the alpha-ear of the AP-2 adaptor. We present structural characterization of these regulatory interactions. DPF and DPW motif peptides derived from eps15 and epsin bind in type I beta turn conformations to a conserved pocket on the alpha-ear platform. We show evidence for a second binding site that is DPW ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| CLTA SYNJ1 | Proximity Label-MS Proximity Label-MS An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods. | High | 46.67 | BioGRID | 2983518 |
Curated By
- BioGRID