BAIT

HSPA4

APG-2, HEL-S-5a, HS24/P52, HSPH2, RY, hsp70, hsp70RY
heat shock 70kDa protein 4
GO Process (3)
GO Function (1)
GO Component (3)

Gene Ontology Biological Process

Gene Ontology Molecular Function

Gene Ontology Cellular Component

Homo sapiens
PREY

NUB1

BS4, NUB1L, NYREN18
negative regulator of ubiquitin-like proteins 1
Alzheimer's Disease Project
UPS Project
Homo sapiens

Co-fractionation

Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex.

Publication

The Leber congenital amaurosis protein AIPL1 functions as part of a chaperone heterocomplex.

Hidalgo-de-Quintana J, Evans RJ, Cheetham ME, van der Spuy J

PURPOSE: AIPL1 mutations cause the severe inherited blindness Leber congenital amaurosis (LCA). The similarity of AIPL1 to tetratricopeptide repeat (TPR) cochaperones that interact with the chaperone Hsp90 and the ability of AIPL1 to suppress the aggregation of NUB1 fragments in a chaperone-like manner suggest that AIPL1 might function as part of a chaperone heterocomplex facilitating retinal protein maturation. In this ... [more]

Invest. Ophthalmol. Vis. Sci. Jul. 01, 2008; 49(7);2878-87 [Pubmed: 18408180]

Throughput

  • Low Throughput

Ontology Terms

  • cell line: retinoblastoma cell line (BTO:0002919)

Curated By

  • BioGRID