ATP7B
Gene Ontology Biological Process
- ATP catabolic process [IMP]
- cellular copper ion homeostasis [IMP]
- cellular zinc ion homeostasis [IMP]
- copper ion export [IDA]
- copper ion import [ISO]
- copper ion transmembrane transport [IMP, ISO]
- copper ion transport [IDA, IMP, ISO]
- intracellular copper ion transport [IMP]
- lactation [IMP]
- response to copper ion [ISO]
- sequestering of calcium ion [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
CLU
Gene Ontology Biological Process
- cell morphogenesis [ISO]
- central nervous system myelin maintenance [ISO]
- chaperone-mediated protein complex assembly [ISO]
- chaperone-mediated protein folding [ISO]
- endocrine pancreas development [ISO]
- intrinsic apoptotic signaling pathway [ISO]
- microglial cell activation [ISO]
- microglial cell proliferation [ISO]
- negative regulation of apoptotic process [ISO]
- negative regulation of beta-amyloid formation [ISO]
- negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage [ISO]
- negative regulation of protein homooligomerization [ISO]
- neuron projection morphogenesis [ISO]
- positive regulation of NF-kappaB transcription factor activity [ISO]
- positive regulation of apoptotic process [ISO]
- positive regulation of cell differentiation [ISO]
- positive regulation of cell proliferation [ISO]
- positive regulation of intrinsic apoptotic signaling pathway [ISO]
- positive regulation of neurofibrillary tangle assembly [ISO]
- positive regulation of neuron death [ISO]
- positive regulation of nitric oxide biosynthetic process [ISO]
- positive regulation of proteasomal ubiquitin-dependent protein catabolic process [ISO]
- positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process [ISO]
- positive regulation of tau-protein kinase activity [ISO]
- positive regulation of tumor necrosis factor production [ISO]
- protein import [ISO]
- protein stabilization [ISO]
- regulation of beta-amyloid clearance [ISO]
- regulation of neuron death [ISO]
- regulation of neuronal signal transduction [ISO]
- response to misfolded protein [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- aggresome [ISO]
- apical dendrite [ISO]
- blood microparticle [ISO]
- cytoplasm [ISO]
- extracellular matrix [ISO]
- extracellular space [ISO]
- extracellular vesicular exosome [ISO]
- growth cone [ISO]
- mitochondrion [ISO]
- neurofibrillary tangle [ISO]
- neuron projection [ISO]
- nucleus [ISO]
- perinuclear region of cytoplasm [ISO]
- spherical high-density lipoprotein particle [ISO]
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Clusterin (apolipoprotein J), a molecular chaperone that facilitates degradation of the copper-ATPases ATP7A and ATP7B.
The copper-transporting P(1B)-type ATPases (Cu-ATPases) ATP7A and ATP7B are key regulators of physiological copper levels. They function to maintain intracellular copper homeostasis by delivering copper to secretory compartments and by trafficking toward the cell periphery to export excess copper. Mutations in the genes encoding ATP7A and ATP7B lead to copper deficiency and toxicity disorders, Menkes and Wilson diseases, respectively. This ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID