TNK2
Gene Ontology Biological Process
- cell differentiation [IBA]
- cell migration [IBA]
- cell surface receptor signaling pathway [TAS]
- innate immune response [IBA]
- negative regulation of catalytic activity [TAS]
- peptidyl-tyrosine autophosphorylation [IBA]
- phosphorylation [IDA]
- positive regulation of peptidyl-tyrosine phosphorylation [IDA]
- regulation of cell proliferation [IBA]
- regulation of clathrin-mediated endocytosis [IDA]
- small GTPase mediated signal transduction [TAS]
- transmembrane receptor protein tyrosine kinase signaling pathway [IBA]
Gene Ontology Molecular Function- GTPase inhibitor activity [TAS]
- WW domain binding [ISS]
- epidermal growth factor receptor binding [IDA]
- hormone receptor binding [IBA]
- non-membrane spanning protein tyrosine kinase activity [IBA]
- protein binding [IPI]
- protein serine/threonine/tyrosine kinase activity [IDA]
- protein tyrosine kinase activity [IDA]
- GTPase inhibitor activity [TAS]
- WW domain binding [ISS]
- epidermal growth factor receptor binding [IDA]
- hormone receptor binding [IBA]
- non-membrane spanning protein tyrosine kinase activity [IBA]
- protein binding [IPI]
- protein serine/threonine/tyrosine kinase activity [IDA]
- protein tyrosine kinase activity [IDA]
Gene Ontology Cellular Component
HCK
Gene Ontology Biological Process
- Fc-gamma receptor signaling pathway involved in phagocytosis [TAS]
- cell adhesion [TAS]
- cell differentiation [IBA]
- cellular response to peptide hormone stimulus [IBA]
- cytokine-mediated signaling pathway [TAS]
- innate immune response [IBA, TAS]
- innate immune response-activating signal transduction [TAS]
- integrin-mediated signaling pathway [TAS]
- interferon-gamma-mediated signaling pathway [TAS]
- leukocyte degranulation [TAS]
- leukocyte migration involved in immune response [TAS]
- lipopolysaccharide-mediated signaling pathway [TAS]
- mesoderm development [TAS]
- negative regulation of apoptotic process [IMP]
- peptidyl-tyrosine autophosphorylation [IBA]
- peptidyl-tyrosine phosphorylation [IMP]
- positive regulation of actin cytoskeleton reorganization [IDA, IMP]
- positive regulation of actin filament polymerization [TAS]
- positive regulation of cell proliferation [IMP]
- protein autophosphorylation [IMP]
- protein phosphorylation [TAS]
- regulation of cell shape [IMP]
- regulation of defense response to virus by virus [TAS]
- regulation of inflammatory response [TAS]
- regulation of phagocytosis [IMP]
- regulation of podosome assembly [IDA]
- regulation of sequence-specific DNA binding transcription factor activity [IMP]
- respiratory burst after phagocytosis [TAS]
- transmembrane receptor protein tyrosine kinase signaling pathway [IBA]
- viral process [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Reconstituted Complex
An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator.
Publication
The Cdc42-associated kinase ACK1 is not autoinhibited but requires Src for activation.
The non-RTK (receptor tyrosine kinase) ACK1 [activated Cdc42 (cell division cycle 42)-associated kinase 1] binds a number of RTKs and is associated with their endocytosis and turnover. Its mode of activation is not well established, but models have suggested that this is an autoinhibited kinase. Point mutations in its SH3 (Src homology 3)- or EGF (epidermal growth factor)-binding domains have ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| HCK TNK2 | Reconstituted Complex Reconstituted Complex An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator. | Low | - | BioGRID | - |
Curated By
- BioGRID