BAIT
LRRK2
AURA17, DARDARIN, PARK8, RIPK7, ROCO2
leucine-rich repeat kinase 2
GO Process (61)
GO Function (21)
GO Component (23)
Gene Ontology Biological Process
- GTP catabolic process [IDA]
- MAPK cascade [IDA]
- activation of MAPK activity [IDA]
- activation of MAPKK activity [IDA]
- cellular protein localization [ISS]
- cellular response to dopamine [IMP]
- cellular response to manganese ion [IMP]
- cellular response to oxidative stress [IMP]
- determination of adult lifespan [IMP]
- endocytosis [IGI, IMP]
- exploration behavior [IMP]
- intracellular distribution of mitochondria [IMP]
- intracellular signal transduction [ISS]
- negative regulation of GTPase activity [IDA]
- negative regulation of hydrogen peroxide-induced cell death [IMP]
- negative regulation of late endosome to lysosome transport [TAS]
- negative regulation of peroxidase activity [IDA]
- negative regulation of protein binding [IMP]
- negative regulation of protein phosphorylation [ISS]
- negative regulation of protein processing [IDA]
- negative regulation of protein processing involved in protein targeting to mitochondrion [IC]
- negative regulation of protein targeting to mitochondrion [IDA]
- negative regulation of thioredoxin peroxidase activity by peptidyl-threonine phosphorylation [IDA]
- neuromuscular junction development [IMP]
- neuron death [IMP]
- neuron projection morphogenesis [IMP]
- olfactory bulb development [IMP]
- peptidyl-serine phosphorylation [IDA]
- peptidyl-threonine phosphorylation [IDA, IMP]
- positive regulation of GTPase activity [IDA]
- positive regulation of MAP kinase activity [IC]
- positive regulation of autophagy [IMP, ISS]
- positive regulation of dopamine receptor signaling pathway [IMP]
- positive regulation of programmed cell death [IDA]
- positive regulation of proteasomal ubiquitin-dependent protein catabolic process [ISS]
- positive regulation of protein autoubiquitination [IDA]
- positive regulation of protein binding [IDA]
- positive regulation of protein phosphorylation [IMP]
- positive regulation of protein ubiquitination [IDA]
- protein autophosphorylation [IDA, IMP]
- protein localization to mitochondrion [TAS]
- protein phosphorylation [IMP]
- reactive oxygen species metabolic process [IMP]
- regulation of branching morphogenesis of a nerve [IMP]
- regulation of dendritic spine morphogenesis [IMP, ISS]
- regulation of dopamine receptor signaling pathway [ISS]
- regulation of excitatory postsynaptic membrane potential [ISS]
- regulation of kidney size [ISS]
- regulation of locomotion [IMP]
- regulation of membrane potential [IMP]
- regulation of mitochondrial depolarization [IMP]
- regulation of mitochondrial fission [TAS]
- regulation of neuroblast proliferation [IMP]
- regulation of neuron death [IMP]
- regulation of neuron maturation [IMP]
- regulation of protein kinase A signaling [ISS]
- regulation of synaptic transmission, glutamatergic [ISS]
- regulation of synaptic vesicle exocytosis [IMP]
- regulation of synaptic vesicle transport [ISS, TAS]
- response to oxidative stress [IMP]
- tangential migration from the subventricular zone to the olfactory bulb [IMP]
Gene Ontology Molecular Function- GTP binding [IDA]
- GTP-dependent protein kinase activity [IDA, IMP]
- GTPase activator activity [IDA]
- GTPase activity [IDA]
- MAP kinase kinase activity [IDA]
- Rho GTPase binding [IPI]
- SNARE binding [IPI]
- actin binding [IPI]
- clathrin binding [IPI]
- glycoprotein binding [IPI]
- identical protein binding [IPI]
- ion channel binding [IPI]
- kinase activity [IDA]
- peroxidase inhibitor activity [IDA]
- protein binding [IPI]
- protein homodimerization activity [IPI]
- protein kinase A binding [IPI]
- protein kinase activity [IDA]
- protein serine/threonine kinase activity [IDA]
- syntaxin-1 binding [IPI]
- tubulin binding [IDA]
- GTP binding [IDA]
- GTP-dependent protein kinase activity [IDA, IMP]
- GTPase activator activity [IDA]
- GTPase activity [IDA]
- MAP kinase kinase activity [IDA]
- Rho GTPase binding [IPI]
- SNARE binding [IPI]
- actin binding [IPI]
- clathrin binding [IPI]
- glycoprotein binding [IPI]
- identical protein binding [IPI]
- ion channel binding [IPI]
- kinase activity [IDA]
- peroxidase inhibitor activity [IDA]
- protein binding [IPI]
- protein homodimerization activity [IPI]
- protein kinase A binding [IPI]
- protein kinase activity [IDA]
- protein serine/threonine kinase activity [IDA]
- syntaxin-1 binding [IPI]
- tubulin binding [IDA]
Gene Ontology Cellular Component
- Golgi apparatus [ISS]
- axon [IDA, ISS]
- cytoplasm [IDA]
- cytoplasmic side of mitochondrial outer membrane [IDA]
- cytoplasmic vesicle [ISS]
- cytosol [IDA]
- dendrite [IDA, ISS]
- dendrite cytoplasm [IDA]
- endoplasmic reticulum [ISS]
- endosome [ISS]
- extracellular space [IDA]
- extracellular vesicular exosome [IDA]
- inclusion body [IMP]
- lysosome [ISS]
- mitochondrial inner membrane [ISS]
- mitochondrial matrix [ISS]
- mitochondrial membrane [IDA]
- mitochondrial outer membrane [ISS]
- mitochondrion [IDA]
- neuron projection [IDA]
- neuronal cell body [IDA]
- perikaryon [IDA, ISS]
- terminal bouton [TAS]
Homo sapiens
PREY
PRKCZ
PKC-ZETA, PKC2, RP11-181G12.1
protein kinase C, zeta
GO Process (21)
GO Function (4)
GO Component (6)
Gene Ontology Biological Process
- blood coagulation [TAS]
- establishment of cell polarity [ISS]
- long-term synaptic potentiation [ISS]
- negative regulation of insulin receptor signaling pathway [IMP]
- negative regulation of peptidyl-tyrosine phosphorylation [IMP]
- negative regulation of protein complex assembly [IMP]
- peptidyl-serine phosphorylation [IDA]
- platelet activation [TAS]
- positive regulation of ERK1 and ERK2 cascade [IMP]
- positive regulation of NF-kappaB transcription factor activity [ISS]
- positive regulation of T-helper 2 cell cytokine production [ISS]
- positive regulation of T-helper 2 cell differentiation [ISS]
- positive regulation of excitatory postsynaptic membrane potential [ISS]
- positive regulation of insulin receptor signaling pathway [ISS]
- positive regulation of interleukin-10 secretion [ISS]
- positive regulation of interleukin-13 secretion [ISS]
- positive regulation of interleukin-4 production [ISS]
- positive regulation of interleukin-5 secretion [ISS]
- protein phosphorylation [IDA]
- signal transduction [TAS]
- transforming growth factor beta receptor signaling pathway [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Biochemical Activity (Phosphorylation)
An interaction is inferred from the biochemical effect of one protein upon another, for example, GTP-GDP exchange activity or phosphorylation of a substrate by a kinase. The bait protein executes the activity on the substrate hit protein. A Modification value is recorded for interactions of this type with the possible values Phosphorylation, Ubiquitination, Sumoylation, Dephosphorylation, Methylation, Prenylation, Acetylation, Deubiquitination, Proteolytic Processing, Glucosylation, Nedd(Rub1)ylation, Deacetylation, No Modification, Demethylation.
Publication
Signal transduction protein array analysis links LRRK2 to Ste20 kinases and PKC zeta that modulate neuronal plasticity.
Dominant mutations in leucine-rich repeat kinase 2 (LRRK2) are the most common genetic cause of Parkinson's disease, however, the underlying pathogenic mechanisms are poorly understood. Several in vitro studies have shown that the most frequent mutation, LRRK2(G2019S), increases kinase activity and impairs neuronal survival. LRRK2 has been linked to the mitogen-activated protein kinase kinase kinase family and the receptor-interacting protein ... [more]
PLoS ONE Oct. 16, 2010; 5(10);e13191 [Pubmed: 20949042]
Throughput
- High Throughput|Low Throughput
Additional Notes
- figure 2.
- table 1.
Curated By
- BioGRID