ABI1
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
BRK1
Gene Ontology Biological Process
- Rac protein signal transduction [ISO]
- actin cytoskeleton organization [IMP]
- cell motility [IMP]
- in utero embryonic development [IMP]
- positive regulation of Arp2/3 complex-mediated actin nucleation [ISO]
- positive regulation of cell proliferation [IMP]
- positive regulation of lamellipodium assembly [ISO]
- protein homotrimerization [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
The proximal signaling network of the BCR-ABL1 oncogene shows a modular organization.
BCR-ABL1 is a fusion tyrosine kinase, which causes multiple types of leukemia. We used an integrated proteomic approach that includes label-free quantitative protein complex and phosphorylation profiling by mass spectrometry to systematically characterize the proximal signaling network of this oncogenic kinase. The proximal BCR-ABL1 signaling network shows a modular and layered organization with an inner core of three leukemia transformation-relevant ... [more]
Throughput
- Low Throughput
Additional Notes
- table S2.
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| ABI1 BRK1 | Co-fractionation Co-fractionation Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex. | High | 0.926 | BioGRID | 2667427 |
Curated By
- BioGRID