BAIT
CRK
Crk-I, Crk-II, Crk-III, Crk3, CrkIII, Crko, c-Crk, p38, RP23-136K12.1
v-crk sarcoma virus CT10 oncogene homolog (avian)
GO Process (5)
GO Function (7)
GO Component (2)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
BCR
5133400C09Rik, AI561783, AI853148, mKIAA3017
breakpoint cluster region
GO Process (14)
GO Function (4)
GO Component (6)
Gene Ontology Biological Process
- actin cytoskeleton organization [IGI]
- brain development [IGI]
- inner ear morphogenesis [IGI]
- negative regulation of cell migration [IGI]
- negative regulation of inflammatory response [IMP]
- negative regulation of neutrophil degranulation [IGI]
- neuromuscular process controlling balance [IGI]
- platelet-derived growth factor receptor signaling pathway [ISO]
- positive regulation of GTPase activity [IDA]
- positive regulation of Rac GTPase activity [IGI]
- positive regulation of phagocytosis [IGI]
- protein autophosphorylation [ISO]
- regulation of cell cycle [IDA]
- response to lipopolysaccharide [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
The proximal signaling network of the BCR-ABL1 oncogene shows a modular organization.
BCR-ABL1 is a fusion tyrosine kinase, which causes multiple types of leukemia. We used an integrated proteomic approach that includes label-free quantitative protein complex and phosphorylation profiling by mass spectrometry to systematically characterize the proximal signaling network of this oncogenic kinase. The proximal BCR-ABL1 signaling network shows a modular and layered organization with an inner core of three leukemia transformation-relevant ... [more]
Oncogene Nov. 04, 2010; 29(44);5895-910 [Pubmed: 20697350]
Throughput
- Low Throughput
Additional Notes
- table S2.
Curated By
- BioGRID