BAIT
CRKL
1110025F07Rik, AA589403, AI325100, Crkol
v-crk sarcoma virus CT10 oncogene homolog (avian)-like
GO Process (7)
GO Function (2)
GO Component (2)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
PRDX1
MSP23, NkefA, OSF-3, OSF3, PAG, Paga, PrdxI, PrxI, TDX2, TPxA, Tdpx2, prx1, RP23-177C18.2
peroxiredoxin 1
GO Process (10)
GO Function (8)
GO Component (11)
Gene Ontology Biological Process
- cell proliferation [IMP]
- erythrocyte homeostasis [IMP]
- hydrogen peroxide catabolic process [ISO]
- natural killer cell mediated cytotoxicity [IMP]
- oxidation-reduction process [ISO]
- regulation of NF-kappaB import into nucleus [IMP]
- regulation of stress-activated MAPK cascade [IMP]
- removal of superoxide radicals [IMP]
- response to oxidative stress [IDA, IMP]
- response to reactive oxygen species [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
The proximal signaling network of the BCR-ABL1 oncogene shows a modular organization.
BCR-ABL1 is a fusion tyrosine kinase, which causes multiple types of leukemia. We used an integrated proteomic approach that includes label-free quantitative protein complex and phosphorylation profiling by mass spectrometry to systematically characterize the proximal signaling network of this oncogenic kinase. The proximal BCR-ABL1 signaling network shows a modular and layered organization with an inner core of three leukemia transformation-relevant ... [more]
Oncogene Nov. 04, 2010; 29(44);5895-910 [Pubmed: 20697350]
Throughput
- Low Throughput
Additional Notes
- table S2.
Curated By
- BioGRID