BAIT
DOK2
DokR, Frip
docking protein 2
GO Process (4)
GO Function (2)
GO Component (1)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
NCK2
4833426I10Rik, Grb4, NCKbeta, Nck-2
non-catalytic region of tyrosine kinase adaptor protein 2
GO Process (9)
GO Function (1)
GO Component (3)
Gene Ontology Biological Process
- actin filament organization [IMP]
- cell migration [IMP]
- dendritic spine development [ISO]
- ephrin receptor signaling pathway [IDA]
- immunological synapse formation [ISO]
- lamellipodium assembly [IMP]
- positive regulation of T cell proliferation [ISO]
- positive regulation of actin filament polymerization [ISO]
- positive regulation of transcription from RNA polymerase II promoter [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
The proximal signaling network of the BCR-ABL1 oncogene shows a modular organization.
BCR-ABL1 is a fusion tyrosine kinase, which causes multiple types of leukemia. We used an integrated proteomic approach that includes label-free quantitative protein complex and phosphorylation profiling by mass spectrometry to systematically characterize the proximal signaling network of this oncogenic kinase. The proximal BCR-ABL1 signaling network shows a modular and layered organization with an inner core of three leukemia transformation-relevant ... [more]
Oncogene Nov. 04, 2010; 29(44);5895-910 [Pubmed: 20697350]
Throughput
- Low Throughput
Additional Notes
- table S2.
Curated By
- BioGRID