BCL6
Gene Ontology Biological Process
- cellular response to DNA damage stimulus [IDA]
- negative regulation of B cell apoptotic process [NAS]
- negative regulation of cell growth [IDA]
- negative regulation of transcription from RNA polymerase II promoter [IDA]
- negative regulation of transcription, DNA-templated [IMP, NAS]
- positive regulation of apoptotic process [IDA]
- protein import into nucleus, translocation [IGI]
- regulation of germinal center formation [NAS]
- regulation of immune response [NAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
CTBP1
Gene Ontology Biological Process
- chromatin organization involved in regulation of transcription [IMP]
- negative regulation of cell proliferation [TAS]
- negative regulation of histone H4 acetylation [IMP]
- negative regulation of histone acetylation [IMP]
- negative regulation of transcription from RNA polymerase II promoter [IMP]
- negative regulation of transcription, DNA-templated [ISS]
- positive regulation of histone deacetylation [IMP]
- protein phosphorylation [TAS]
- regulation of cell cycle [IMP]
- viral genome replication [TAS]
- white fat cell differentiation [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Reconstituted Complex
An interaction is detected between purified proteins in vitro.
Publication
CtBP is an essential corepressor for BCL6 autoregulation.
The transcription repressor BCL6 plays an essential role in the formation and function of germinal centers (GCs). While normal B cells promptly shut off BCL6 when they exit the GC, many GC-derived B-cell lymphomas sustain BCL6 expression through chromosomal translocations and activating mutations. We have previously shown that a common effect of lymphoma-associated BCL6 gene alterations is to bypass a ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| CTBP1 BCL6 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - | |
| BCL6 CTBP1 | Co-localization Co-localization Interaction inferred from two proteins that co-localize in the cell by indirect immunofluorescence only when in addition, if one gene is deleted, the other protein becomes mis-localized. Also includes co-dependent association of proteins with promoter DNA in chromatin immunoprecipitation experiments. | Low | - | BioGRID | 722935 |
Curated By
- BioGRID