BAIT
CRYGC
CCL, CRYG3, CTRCT2
crystallin, gamma C
GO Process (1)
GO Function (2)
GO Component (2)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Homo sapiens
PREY
CRYGD
CACA, CCA3, CCP, CRYG4, CTRCT4, PCC, cry-g-D
crystallin, gamma D
GO Process (4)
GO Function (2)
GO Component (2)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Alteration of protein-protein interactions of congenital cataract crystallin mutants.
A recent study demonstrated the presence of protein-protein interactions among lens crystallins in a mammalian cell two-hybrid system assay and speculated about the significance of these interactions for protein solubility and lens transparency. The current study extends those findings to the following crystallin genes involved in some congenital cataracts: CRYAA (R116C), CRYAB (R120G), and CRYGC (T5P).A mammalian two-hybrid system was ... [more]
Invest. Ophthalmol. Vis. Sci. Mar. 01, 2003; 44(3);1155-9 [Pubmed: 12601044]
Throughput
- Low Throughput
Additional Notes
- mammalian two-hybrid system
Curated By
- BioGRID