BAIT
CRYAB
CMD1II, CRYA2, CTPP2, CTRCT16, HEL-S-101, HSPB5, MFM2
crystallin, alpha B
GO Process (6)
GO Function (4)
GO Component (3)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Homo sapiens
PREY
CD40LG
CD154, CD40L, HIGM1, IGM, IMD3, T-BAM, TNFSF5, TRAP, gp39, hCD40L, RP3-527F8.3
CD40 ligand
GO Process (9)
GO Function (1)
GO Component (3)
Gene Ontology Biological Process
- B cell proliferation [IDA]
- inflammatory response [IDA]
- isotype switching [ISS]
- leukocyte cell-cell adhesion [NAS]
- negative regulation of apoptotic process [IDA]
- platelet activation [IDA]
- positive regulation of endothelial cell apoptotic process [IDA]
- positive regulation of interleukin-12 production [IDA]
- regulation of immune response [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Chaperone activity of α B-crystallin is responsible for its incorrect assignment as an autoantigen in multiple sclerosis.
For 15 y, α B-crystallin (heat shock protein [Hsp] B5) has been labeled an autoantigen in multiple sclerosis (MS) based on humoral and cellular responses found in humans and animal models. However, there have been several scientific inconsistencies with this assignment, ranging from studies demonstrating small differences in anticrystallin responses between patients and healthy individuals to the inability of crystallin-specific ... [more]
J. Immunol. Apr. 01, 2011; 186(7);4263-8 [Pubmed: 21357544]
Throughput
- Low Throughput
Curated By
- BioGRID