DNM1L
Gene Ontology Biological Process
- GTP catabolic process [ISO]
- dynamin polymerization involved in mitochondrial fission [ISO]
- membrane fission involved in mitochondrial fission [ISO]
- membrane fusion [ISO]
- mitochondrial fission [IMP, ISO]
- mitochondrial fragmentation involved in apoptotic process [ISO]
- mitochondrion morphogenesis [ISO]
- necroptotic process [IMP, ISO]
- peroxisome fission [ISO]
- positive regulation of apoptotic process [ISO]
- positive regulation of intrinsic apoptotic signaling pathway [ISO]
- positive regulation of protein secretion [ISO]
- positive regulation of release of cytochrome c from mitochondria [ISO]
- protein homotetramerization [ISO]
- protein localization to mitochondrion [IMP]
- regulation of mitochondrion organization [ISO]
- regulation of peroxisome organization [ISO]
- regulation of protein oligomerization [ISO]
- release of cytochrome c from mitochondria [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
LRRK2
Gene Ontology Biological Process
- GTP catabolic process [ISO]
- MAPK cascade [ISO]
- activation of MAPK activity [ISO]
- activation of MAPKK activity [ISO]
- cellular response to dopamine [ISO]
- cellular response to manganese ion [ISO]
- cellular response to oxidative stress [ISO]
- determination of adult lifespan [ISO]
- endocytosis [ISO]
- exploration behavior [ISO]
- intracellular distribution of mitochondria [ISO]
- negative regulation of GTPase activity [ISO]
- negative regulation of hydrogen peroxide-induced cell death [ISO]
- negative regulation of peroxidase activity [ISO]
- negative regulation of protein binding [ISO]
- negative regulation of protein processing [ISO]
- negative regulation of protein targeting to mitochondrion [ISO]
- negative regulation of thioredoxin peroxidase activity by peptidyl-threonine phosphorylation [ISO]
- neuromuscular junction development [ISO]
- neuron death [ISO]
- neuron projection morphogenesis [ISO]
- olfactory bulb development [ISO]
- peptidyl-serine phosphorylation [ISO]
- peptidyl-threonine phosphorylation [ISO]
- positive regulation of GTPase activity [ISO]
- positive regulation of autophagy [IMP, ISO]
- positive regulation of dopamine receptor signaling pathway [ISO]
- positive regulation of programmed cell death [ISO]
- positive regulation of proteasomal ubiquitin-dependent protein catabolic process [IMP]
- positive regulation of protein autoubiquitination [ISO]
- positive regulation of protein binding [ISO]
- positive regulation of protein phosphorylation [ISO]
- positive regulation of protein ubiquitination [ISO]
- protein autophosphorylation [ISA, ISO]
- protein phosphorylation [ISA, ISO]
- reactive oxygen species metabolic process [ISO]
- regulation of branching morphogenesis of a nerve [ISO]
- regulation of dendritic spine morphogenesis [ISO]
- regulation of kidney size [IMP]
- regulation of locomotion [ISO]
- regulation of membrane potential [ISO]
- regulation of mitochondrial depolarization [ISO]
- regulation of neuroblast proliferation [ISO]
- regulation of neuron death [ISO]
- regulation of neuron maturation [ISO]
- regulation of synaptic vesicle exocytosis [ISO]
- response to oxidative stress [ISO]
- tangential migration from the subventricular zone to the olfactory bulb [ISO]
Gene Ontology Molecular Function- GTP binding [ISA, ISO]
- GTP-dependent protein kinase activity [ISA, ISO]
- GTPase activator activity [ISO]
- GTPase activity [ISO]
- MAP kinase kinase activity [ISO]
- Rho GTPase binding [IPI, ISO]
- SNARE binding [ISO]
- actin binding [ISO]
- clathrin binding [ISO]
- glycoprotein binding [ISO]
- identical protein binding [IPI, ISO]
- ion channel binding [ISO]
- kinase activity [ISO]
- peroxidase inhibitor activity [ISO]
- protein binding [IPI]
- protein homodimerization activity [ISO]
- protein kinase A binding [ISO]
- protein kinase activity [ISO]
- protein serine/threonine kinase activity [ISO]
- syntaxin-1 binding [ISO]
- tubulin binding [ISO]
- GTP binding [ISA, ISO]
- GTP-dependent protein kinase activity [ISA, ISO]
- GTPase activator activity [ISO]
- GTPase activity [ISO]
- MAP kinase kinase activity [ISO]
- Rho GTPase binding [IPI, ISO]
- SNARE binding [ISO]
- actin binding [ISO]
- clathrin binding [ISO]
- glycoprotein binding [ISO]
- identical protein binding [IPI, ISO]
- ion channel binding [ISO]
- kinase activity [ISO]
- peroxidase inhibitor activity [ISO]
- protein binding [IPI]
- protein homodimerization activity [ISO]
- protein kinase A binding [ISO]
- protein kinase activity [ISO]
- protein serine/threonine kinase activity [ISO]
- syntaxin-1 binding [ISO]
- tubulin binding [ISO]
Gene Ontology Cellular Component
- Golgi apparatus [IDA]
- axon [ISO]
- cytoplasm [ISO]
- cytoplasmic side of mitochondrial outer membrane [ISO]
- cytoplasmic vesicle [IDA]
- cytosol [ISO]
- dendrite [ISO]
- dendrite cytoplasm [ISO]
- endoplasmic reticulum [IDA]
- endosome [IDA]
- extracellular space [ISO]
- extracellular vesicular exosome [ISO]
- inclusion body [ISO]
- intracellular membrane-bounded organelle [ISO]
- lysosome [IDA]
- membrane [ISO]
- membrane raft [IDA]
- mitochondrial inner membrane [IDA]
- mitochondrial matrix [IDA]
- mitochondrial membrane [ISO]
- mitochondrial outer membrane [IDA]
- mitochondrion [ISO]
- neuron projection [ISO]
- neuronal cell body [ISO]
- perikaryon [ISO]
- plasma membrane [IDA]
- synapse [IDA]
- synaptic vesicle [IDA]
- trans-Golgi network [IDA]
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Leucine-rich repeat kinase 2 disturbs mitochondrial dynamics via Dynamin-like protein.
Mutations in Leucine-rich repeat kinase 2 (LRRK2) are the leading causes of genetically inherited Parkinson's disease (PD) identified so far. The underlying mechanism whereby missense alterations in LRRK2 initiate neurodegeneration remains largely unclear. Mitochondrial dysfunction has been recognized to contribute to the pathogenesis of both sporadic and familial PD. The pathogenic gain-of-function mutant form of LRRK2, LRRK2 G2019S, is associated ... [more]
Throughput
- Low Throughput
Additional Notes
- figure 2.
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| LRRK2 DNM1L | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | 723179 |
Curated By
- BioGRID