BAIT

DNM1L

6330417M19Rik, AI450666, Dlp1, Dnmlp1, Drp1, python
dynamin 1-like
Mus musculus
PREY

LRRK2

4921513O20Rik, 9330188B09Rik, AW561911, D630001M17Rik, Gm927, cI-46
leucine-rich repeat kinase 2
GO Process (48)
GO Function (21)
GO Component (29)

Gene Ontology Biological Process

Mus musculus

Affinity Capture-Western

An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.

Publication

Leucine-rich repeat kinase 2 disturbs mitochondrial dynamics via Dynamin-like protein.

Niu J, Yu M, Wang C, Xu Z

Mutations in Leucine-rich repeat kinase 2 (LRRK2) are the leading causes of genetically inherited Parkinson's disease (PD) identified so far. The underlying mechanism whereby missense alterations in LRRK2 initiate neurodegeneration remains largely unclear. Mitochondrial dysfunction has been recognized to contribute to the pathogenesis of both sporadic and familial PD. The pathogenic gain-of-function mutant form of LRRK2, LRRK2 G2019S, is associated ... [more]

J. Neurochem. Aug. 01, 2012; 122(3);650-8 [Pubmed: 22639965]

Throughput

  • Low Throughput

Additional Notes

  • figure 2.

Related interactions

InteractionExperimental Evidence CodeDatasetThroughputScoreCurated ByNotes
LRRK2 DNM1L
Affinity Capture-Western
Affinity Capture-Western

An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.

Low-BioGRID
723179

Curated By

  • BioGRID