FIS1
Gene Ontology Biological Process
- calcium-mediated signaling using intracellular calcium source [IMP]
- mitochondrial fission [IDA, IMP]
- mitochondrial fragmentation involved in apoptotic process [IDA, IMP]
- mitochondrial fusion [IMP]
- mitochondrion degradation [IDA]
- mitochondrion morphogenesis [IMP]
- negative regulation of endoplasmic reticulum calcium ion concentration [IMP]
- peroxisome fission [IDA, IMP]
- positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [IMP]
- positive regulation of cytosolic calcium ion concentration [IMP]
- positive regulation of intrinsic apoptotic signaling pathway [IMP]
- positive regulation of mitochondrial calcium ion concentration [IMP]
- positive regulation of mitochondrial fission [IDA]
- positive regulation of protein targeting to membrane [IDA]
- protein homooligomerization [IMP]
- protein targeting to mitochondrion [IMP]
- regulation of mitochondrion organization [IMP]
- release of cytochrome c from mitochondria [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
CASP8
Gene Ontology Biological Process
- B cell activation [TAS]
- MyD88-independent toll-like receptor signaling pathway [TAS]
- T cell activation [TAS]
- TRAIL-activated apoptotic signaling pathway [IDA]
- TRIF-dependent toll-like receptor signaling pathway [TAS]
- activation of cysteine-type endopeptidase activity [IDA]
- activation of cysteine-type endopeptidase activity involved in apoptotic process [TAS]
- apoptotic process [IGI, IMP, TAS]
- apoptotic signaling pathway [IMP, TAS]
- cellular component disassembly involved in execution phase of apoptosis [TAS]
- cellular response to mechanical stimulus [IEP]
- execution phase of apoptosis [IMP]
- extrinsic apoptotic signaling pathway [IDA]
- extrinsic apoptotic signaling pathway via death domain receptors [IBA]
- innate immune response [TAS]
- intrinsic apoptotic signaling pathway [TAS]
- macrophage differentiation [TAS]
- natural killer cell activation [TAS]
- negative regulation of I-kappaB kinase/NF-kappaB signaling [IMP]
- nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway [TAS]
- nucleotide-binding oligomerization domain containing signaling pathway [TAS]
- positive regulation of I-kappaB kinase/NF-kappaB signaling [IEP, IMP]
- positive regulation of macrophage differentiation [IMP]
- positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway [TAS]
- positive regulation of proteolysis [IDA]
- proteolysis [IDA]
- proteolysis involved in cellular protein catabolic process [IMP]
- regulation of extrinsic apoptotic signaling pathway in absence of ligand [TAS]
- response to tumor necrosis factor [IMP]
- syncytiotrophoblast cell differentiation involved in labyrinthine layer development [TAS]
- toll-like receptor 3 signaling pathway [TAS]
- toll-like receptor 4 signaling pathway [TAS]
- toll-like receptor signaling pathway [TAS]
Gene Ontology Molecular Function- cysteine-type endopeptidase activity [IDA, TAS]
- cysteine-type endopeptidase activity involved in apoptotic process [IMP]
- cysteine-type endopeptidase activity involved in apoptotic signaling pathway [IMP]
- cysteine-type peptidase activity [TAS]
- death effector domain binding [IPI]
- peptidase activity [IMP]
- protein binding [IPI]
- scaffold protein binding [IPI]
- ubiquitin protein ligase binding [IPI]
- cysteine-type endopeptidase activity [IDA, TAS]
- cysteine-type endopeptidase activity involved in apoptotic process [IMP]
- cysteine-type endopeptidase activity involved in apoptotic signaling pathway [IMP]
- cysteine-type peptidase activity [TAS]
- death effector domain binding [IPI]
- peptidase activity [IMP]
- protein binding [IPI]
- scaffold protein binding [IPI]
- ubiquitin protein ligase binding [IPI]
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Fis1 and Bap31 bridge the mitochondria-ER interface to establish a platform for apoptosis induction.
The mitochondria and the endoplasmic reticulum (ER) are two organelles that critically contribute to apoptosis induction. While it is established that they communicate, how cell death signals are transmitted from the mitochondria to the ER is unknown. Here, we show that the mitochondrial fission protein Fission 1 homologue (Fis1) conveys an apoptosis signal from the mitochondria to the ER by ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID