BAIT

MBNL1

EXP, EXP35, EXP40, EXP42, MBNL
muscleblind-like splicing regulator 1
Homo sapiens
PREY

BIN1

AMPH2, AMPHL, SH3P9
bridging integrator 1
Alzheimer's Disease Project
UPS Project
Homo sapiens

Protein-RNA

An interaction is detected between and protein and an RNA in vitro.

Publication

Misregulated alternative splicing of BIN1 is associated with T tubule alterations and muscle weakness in myotonic dystrophy.

Fugier C, Klein AF, Hammer C, Vassilopoulos S, Ivarsson Y, Toussaint A, Tosch V, Vignaud A, Ferry A, Messaddeq N, Kokunai Y, Tsuburaya R, de la Grange P, Dembele D, Francois V, Precigout G, Boulade-Ladame C, Hummel MC, Lopez de Munain A, Sergeant N, Laquerriere A, Thibault C, Deryckere F, Auboeuf D, Garcia L, Zimmermann P, Udd B, Schoser B, Takahashi MP, Nishino I, Bassez G, Laporte J, Furling D, Charlet-Berguerand N

Myotonic dystrophy is the most common muscular dystrophy in adults and the first recognized example of an RNA-mediated disease. Congenital myotonic dystrophy (CDM1) and myotonic dystrophy of type 1 (DM1) or of type 2 (DM2) are caused by the expression of mutant RNAs containing expanded CUG or CCUG repeats, respectively. These mutant RNAs sequester the splicing regulator Muscleblind-like-1 (MBNL1), resulting ... [more]

Nat. Med. Jun. 01, 2011; 17(6);720-5 [Pubmed: 21623381]

Throughput

  • Low Throughput

Curated By

  • BioGRID