NF1
Gene Ontology Biological Process
- MAPK cascade [ISO, ISS]
- Ras protein signal transduction [ISO, ISS]
- Schwann cell development [ISO, ISS]
- actin cytoskeleton organization [ISO, ISS]
- adrenal gland development [ISO, ISS]
- artery morphogenesis [ISO, ISS]
- brain development [ISO, ISS]
- camera-type eye morphogenesis [ISO, ISS]
- cell communication [ISO, ISS]
- cerebral cortex development [ISO, ISS]
- cognition [ISO]
- collagen fibril organization [ISO, ISS]
- extracellular matrix organization [ISO, ISS]
- extrinsic apoptotic signaling pathway via death domain receptors [ISO]
- forebrain astrocyte development [ISO, ISS]
- forebrain morphogenesis [ISO, ISS]
- heart development [ISO, ISS]
- liver development [ISO, ISS]
- metanephros development [ISO, ISS]
- myelination in peripheral nervous system [ISO, ISS]
- negative regulation of MAP kinase activity [ISO, ISS]
- negative regulation of MAPK cascade [ISO, ISS]
- negative regulation of Rac protein signal transduction [ISO]
- negative regulation of Ras protein signal transduction [IBA, ISO]
- negative regulation of angiogenesis [ISO]
- negative regulation of astrocyte differentiation [ISO]
- negative regulation of cell migration [ISO]
- negative regulation of cell proliferation [ISO]
- negative regulation of cell-matrix adhesion [ISO]
- negative regulation of endothelial cell proliferation [ISO]
- negative regulation of fibroblast proliferation [ISO, ISS]
- negative regulation of neuroblast proliferation [ISO, ISS]
- negative regulation of neurotransmitter secretion [ISO]
- negative regulation of oligodendrocyte differentiation [ISO, ISS]
- negative regulation of osteoclast differentiation [ISO]
- negative regulation of protein kinase activity [ISO, ISS]
- negative regulation of transcription factor import into nucleus [ISO, ISS]
- neural tube development [ISO]
- osteoblast differentiation [ISO, ISS]
- peripheral nervous system development [ISO, ISS]
- phosphatidylinositol 3-kinase signaling [ISO, ISS]
- pigmentation [ISO, ISS]
- positive regulation of Ras GTPase activity [IBA, ISO, ISS]
- positive regulation of adenylate cyclase activity [ISO, ISS]
- positive regulation of apoptotic process [ISO, ISS]
- positive regulation of endothelial cell proliferation [ISO]
- positive regulation of extrinsic apoptotic signaling pathway in absence of ligand [ISO]
- positive regulation of extrinsic apoptotic signaling pathway via death domain receptors [ISO]
- positive regulation of neuron apoptotic process [ISO, ISS]
- regulation of Ras GTPase activity [IMP, ISO]
- regulation of angiogenesis [ISO, ISS]
- regulation of blood vessel endothelial cell migration [ISO]
- regulation of bone resorption [ISO, ISS]
- regulation of cell proliferation [ISO]
- regulation of cell-matrix adhesion [ISO, ISS]
- regulation of glial cell differentiation [ISO, ISS]
- regulation of long-term neuronal synaptic plasticity [ISO]
- regulation of neuron differentiation [IMP]
- regulation of synaptic transmission, GABAergic [ISO]
- response to hypoxia [ISO, ISS]
- skeletal muscle tissue development [ISO]
- smooth muscle tissue development [ISO, ISS]
- spinal cord development [ISO, ISS]
- sympathetic nervous system development [ISO, ISS]
- visual learning [ISO, ISS]
- wound healing [ISO, ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
VCP
Gene Ontology Biological Process
- ATP catabolic process [IDA, IMP]
- ER to Golgi vesicle-mediated transport [IMP]
- ER-associated ubiquitin-dependent protein catabolic process [ISO, ISS]
- activation of cysteine-type endopeptidase activity involved in apoptotic process [ISO]
- aggresome assembly [ISO]
- cellular response to DNA damage stimulus [ISO, ISS]
- double-strand break repair [ISO, ISS]
- positive regulation of Lys63-specific deubiquitinase activity [ISO]
- positive regulation of proteasomal ubiquitin-dependent protein catabolic process [IMP, ISO]
- positive regulation of protein K63-linked deubiquitination [ISO]
- positive regulation of protein catabolic process [ISO]
- positive regulation of protein complex assembly [ISO]
- protein N-linked glycosylation via asparagine [ISO, ISS]
- protein hexamerization [IDA]
- protein homooligomerization [IDA]
- protein ubiquitination [ISO, ISS]
- retrograde protein transport, ER to cytosol [ISO]
- translesion synthesis [ISO, ISS]
- ubiquitin-dependent protein catabolic process [ISO]
Gene Ontology Molecular Function- ADP binding [IMP]
- ATP binding [IDA, IMP]
- ATPase activity [IDA, IMP]
- deubiquitinase activator activity [ISO]
- identical protein binding [IDA]
- poly(A) RNA binding [ISO]
- polyubiquitin binding [ISO]
- protein binding [IPI]
- protein complex binding [IPI]
- protein domain specific binding [ISO]
- protein phosphatase binding [ISO]
- receptor binding [IDA]
- ubiquitin-specific protease binding [ISO]
- ADP binding [IMP]
- ATP binding [IDA, IMP]
- ATPase activity [IDA, IMP]
- deubiquitinase activator activity [ISO]
- identical protein binding [IDA]
- poly(A) RNA binding [ISO]
- polyubiquitin binding [ISO]
- protein binding [IPI]
- protein complex binding [IPI]
- protein domain specific binding [ISO]
- protein phosphatase binding [ISO]
- receptor binding [IDA]
- ubiquitin-specific protease binding [ISO]
Gene Ontology Cellular Component
- Hrd1p ubiquitin ligase complex [ISO]
- cytoplasm [ISO]
- cytosol [IDA, ISO]
- endoplasmic reticulum [IDA, ISO]
- endoplasmic reticulum membrane [ISO]
- extracellular vesicular exosome [ISO]
- intracellular membrane-bounded organelle [IDA]
- lipid particle [ISO]
- myelin sheath [ISO]
- nucleoplasm [ISO]
- nucleus [ISO]
- perinuclear region of cytoplasm [ISO]
- proteasome complex [ISO]
- protein complex [ISO]
- site of double-strand break [ISO, ISS]
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Valosin-containing protein and neurofibromin interact to regulate dendritic spine density.
Inclusion body myopathy with Paget disease of bone and frontotemporal dementia (IBMPFD) is an autosomal dominant disorder characterized by progressive myopathy that is often accompanied by bone weakening and/or frontotemporal dementia. Although it is known to be caused by mutations in the gene encoding valosin-containing protein (VCP), the underlying disease mechanism remains elusive. Like IBMPFD, neurofibromatosis type 1 (NF1) is ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| VCP NF1 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - |
Curated By
- BioGRID