BRSK2
Gene Ontology Biological Process
- G2/M transition of mitotic cell cycle [IMP]
- actin cytoskeleton reorganization [IMP]
- axonogenesis [ISS]
- establishment of cell polarity [ISS]
- intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [IMP]
- neuron differentiation [ISS]
- protein phosphorylation [IDA]
- regulation of insulin secretion involved in cellular response to glucose stimulus [IMP, ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
CDC25C
Gene Ontology Biological Process
Gene Ontology Molecular Function
Biochemical Activity (Phosphorylation)
An interaction is inferred from the biochemical effect of one protein upon another, for example, GTP-GDP exchange activity or phosphorylation of a substrate by a kinase. The bait protein executes the activity on the substrate hit protein. A Modification value is recorded for interactions of this type with the possible values Phosphorylation, Ubiquitination, Sumoylation, Dephosphorylation, Methylation, Prenylation, Acetylation, Deubiquitination, Proteolytic Processing, Glucosylation, Nedd(Rub1)ylation, Deacetylation, No Modification, Demethylation.
Publication
Human SAD1 kinase is involved in UV-induced DNA damage checkpoint function.
Checkpoint activation by DNA damage during G(2) prevents activation of cyclin B/Cdc2 complexes, and as a consequence, mitotic entry is blocked. Although initiation and maintenance of G(2) arrest are known to be regulated by at least two distinct signaling pathways, including those of p38MAPK and ataxia-telangiectasia-mutated (ATM)- and Rad3-related (ATR)-Chk1 in higher eukaryotes, the actual number of signaling pathways involved ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID