BAIT
USP4
UNP, Unph
ubiquitin specific peptidase 4 (proto-oncogene)
GO Process (7)
GO Function (6)
GO Component (4)
Gene Ontology Biological Process
- negative regulation of protein ubiquitination [IMP]
- proteasome-mediated ubiquitin-dependent protein catabolic process [IBA]
- protein deubiquitination [IDA, IMP]
- protein localization to cell surface [IDA]
- regulation of proteasomal protein catabolic process [IBA]
- regulation of protein stability [IDA]
- spliceosomal tri-snRNP complex assembly [IMP]
Gene Ontology Molecular Function
Homo sapiens
PREY
ATP1B1
ATP1B
ATPase, Na+/K+ transporting, beta 1 polypeptide
GO Process (25)
GO Function (5)
GO Component (6)
Gene Ontology Biological Process
- blood coagulation [TAS]
- cardiac muscle contraction [ISS]
- cell communication by electrical coupling involved in cardiac conduction [TAS]
- cellular calcium ion homeostasis [ISS]
- cellular potassium ion homeostasis [IDA]
- cellular sodium ion homeostasis [IDA]
- ion transmembrane transport [TAS]
- leukocyte migration [TAS]
- membrane repolarization [IDA]
- membrane repolarization during cardiac muscle cell action potential [IC]
- positive regulation of ATP catabolic process [IDA]
- positive regulation of ATPase activity [IDA]
- positive regulation of calcium:sodium antiporter activity [ISS]
- positive regulation of potassium ion import [IDA]
- positive regulation of potassium ion transmembrane transporter activity [IDA]
- positive regulation of sodium ion export from cell [IDA]
- potassium ion import [IDA]
- protein localization to plasma membrane [IDA]
- protein stabilization [IDA, ISS]
- protein transport into plasma membrane raft [TAS]
- regulation of cardiac muscle contraction by calcium ion signaling [ISS]
- regulation of gene expression [ISS]
- relaxation of cardiac muscle [ISS]
- sodium ion export from cell [IDA]
- transmembrane transport [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
The ubiquitin specific protease-4 (USP4) interacts with the S9/Rpn6 subunit of the proteasome.
The proteasome is the major non-lysosomal proteolytic machine in cells that, through degradation of ubiquitylated substrates, regulates virtually all cellular functions. Numerous accessory proteins influence the activity of the proteasome by recruiting or deubiquitylating proteasomal substrates, or by maintaining the integrity of the complex. Here we show that the ubiquitin specific protease (USP)-4, a deubiquitylating enzyme with specificity for both ... [more]
Biochem. Biophys. Res. Commun. Oct. 26, 2012; 427(3);490-6 [Pubmed: 23022198]
Throughput
- Low Throughput
Curated By
- BioGRID