BAIT
USP4
UNP, Unph
ubiquitin specific peptidase 4 (proto-oncogene)
GO Process (7)
GO Function (6)
GO Component (4)
Gene Ontology Biological Process
- negative regulation of protein ubiquitination [IMP]
- proteasome-mediated ubiquitin-dependent protein catabolic process [IBA]
- protein deubiquitination [IDA, IMP]
- protein localization to cell surface [IDA]
- regulation of proteasomal protein catabolic process [IBA]
- regulation of protein stability [IDA]
- spliceosomal tri-snRNP complex assembly [IMP]
Gene Ontology Molecular Function
Homo sapiens
PREY
ASS1
ASS, CTLN1, RP11-618A20.2
argininosuccinate synthase 1
GO Process (10)
GO Function (4)
GO Component (3)
Gene Ontology Biological Process
- arginine biosynthetic process [IBA]
- argininosuccinate metabolic process [IMP]
- aspartate metabolic process [IMP]
- cellular nitrogen compound metabolic process [TAS]
- cellular response to laminar fluid shear stress [IMP]
- citrulline metabolic process [IMP]
- negative regulation of leukocyte cell-cell adhesion [IMP]
- positive regulation of nitric oxide biosynthetic process [IMP]
- small molecule metabolic process [TAS]
- urea cycle [IMP, TAS]
Gene Ontology Molecular Function
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
The ubiquitin specific protease-4 (USP4) interacts with the S9/Rpn6 subunit of the proteasome.
The proteasome is the major non-lysosomal proteolytic machine in cells that, through degradation of ubiquitylated substrates, regulates virtually all cellular functions. Numerous accessory proteins influence the activity of the proteasome by recruiting or deubiquitylating proteasomal substrates, or by maintaining the integrity of the complex. Here we show that the ubiquitin specific protease (USP)-4, a deubiquitylating enzyme with specificity for both ... [more]
Biochem. Biophys. Res. Commun. Oct. 26, 2012; 427(3);490-6 [Pubmed: 23022198]
Throughput
- Low Throughput
Curated By
- BioGRID