BAIT
SOD1
ALS, ALS1, HEL-S-44, IPOA, SOD, hSod1, homodimer
superoxide dismutase 1, soluble
GO Process (50)
GO Function (9)
GO Component (17)
Gene Ontology Biological Process
- activation of MAPK activity [ISS]
- anterograde axon cargo transport [ISS]
- auditory receptor cell stereocilium organization [ISS]
- blood coagulation [TAS]
- cell aging [IMP]
- cellular iron ion homeostasis [ISS]
- embryo implantation [ISS, NAS]
- glutathione metabolic process [ISS]
- heart contraction [IDA]
- hydrogen peroxide biosynthetic process [IDA, ISS]
- locomotory behavior [ISS]
- muscle cell cellular homeostasis [ISS]
- myeloid cell homeostasis [ISS]
- negative regulation of cholesterol biosynthetic process [IDA]
- negative regulation of neuron apoptotic process [ISS]
- neurofilament cytoskeleton organization [ISS]
- ovarian follicle development [ISS]
- peripheral nervous system myelin maintenance [ISS]
- placenta development [NAS]
- platelet activation [TAS]
- platelet degranulation [TAS]
- positive regulation of apoptotic process [IC]
- positive regulation of catalytic activity [IDA]
- positive regulation of cytokine production [IDA]
- positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway [IMP]
- positive regulation of superoxide anion generation [IDA]
- reactive oxygen species metabolic process [IDA]
- regulation of Rac GTPase activity [IDA]
- regulation of T cell differentiation in thymus [NAS]
- regulation of blood pressure [ISS]
- regulation of mitochondrial membrane potential [IMP]
- regulation of multicellular organism growth [ISS]
- regulation of organ growth [NAS]
- regulation of protein kinase activity [IDA]
- relaxation of vascular smooth muscle [ISS]
- removal of superoxide radicals [IBA, IC, ISS]
- response to axon injury [ISS]
- response to drug [ISS]
- response to ethanol [ISS]
- response to heat [ISS]
- response to hydrogen peroxide [ISS]
- response to organic substance [IDA]
- response to superoxide [IDA]
- retina homeostasis [ISS]
- retrograde axon cargo transport [ISS]
- sensory perception of sound [ISS]
- spermatogenesis [ISS]
- superoxide metabolic process [IDA, ISS]
- thymus development [NAS]
- transmission of nerve impulse [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- cytoplasm [IDA]
- cytoplasmic vesicle [IDA]
- cytosol [IDA, TAS]
- dendrite cytoplasm [IDA]
- extracellular matrix [IDA]
- extracellular region [TAS]
- extracellular space [IDA]
- extracellular vesicular exosome [IDA]
- mitochondrial intermembrane space [TAS]
- mitochondrial matrix [NAS]
- mitochondrion [IDA]
- neuronal cell body [IDA]
- nucleoplasm [IDA]
- nucleus [IDA]
- peroxisome [IDA, ISS]
- plasma membrane [IDA]
- protein complex [IDA]
Homo sapiens
PREY
HSPH1
105kDa, AI790491, Hsp105, Hsp110, hsp-E7I
heat shock 105kDa/110kDa protein 1
GO Process (11)
GO Function (2)
GO Component (7)
Gene Ontology Biological Process
- chaperone mediated protein folding requiring cofactor [IDA]
- establishment of protein localization to mitochondrion [IMP]
- intrinsic apoptotic signaling pathway in response to hydrogen peroxide [IMP]
- negative regulation of apoptotic signaling pathway [IMP]
- negative regulation of neuron apoptotic process [TAS]
- positive regulation of MHC class I biosynthetic process [TAS]
- positive regulation of NK T cell activation [TAS]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- regulation of microtubule cytoskeleton organization [NAS]
- regulation of p38MAPK cascade [IGI]
- response to unfolded protein [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Progressive aggregation despite chaperone associations of a mutant SOD1-YFP in transgenic mice that develop ALS.
Recent studies suggest that superoxide dismutase 1 (SOD1)-linked amyotrophic lateral sclerosis results from destabilization and misfolding of mutant forms of this abundant cytosolic enzyme. Here, we have tracked the expression and fate of a misfolding-prone human SOD1, G85R, fused to YFP, in a line of transgenic G85R SOD1-YFP mice. These mice, but not wild-type human SOD1-YFP transgenics, developed lethal paralyzing ... [more]
Proc. Natl. Acad. Sci. U.S.A. Feb. 03, 2009; 106(5);1392-7 [Pubmed: 19171884]
Throughput
- Low Throughput
Additional Notes
- hit proteins identified by MudPIT
- human Sod1 expressed in mice
Curated By
- BioGRID