BAIT
BAP1
2300006C11Rik, AA989761, AW553466, mKIAA0272, uch-x4
Brca1 associated protein 1
GO Process (8)
GO Function (4)
GO Component (4)
Gene Ontology Biological Process
- monoubiquitinated histone H2A deubiquitination [ISO]
- monoubiquitinated protein deubiquitination [ISO]
- negative regulation of cell proliferation [ISA]
- protein K48-linked deubiquitination [ISO]
- protein deubiquitination [ISA, ISO]
- proteolysis [ISO]
- regulation of cell cycle [ISO]
- regulation of cell growth [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- PR-DUB complex [ISO]
- cytoplasm [ISO]
- nucleoplasm [ISO]
- nucleus [ISA, ISO]
Mus musculus
PREY
ASXL2
4930556B16Rik, mKIAA1685, mCG_140115
additional sex combs like 2 (Drosophila)
GO Process (11)
GO Function (1)
GO Component (3)
Gene Ontology Biological Process
- adult heart development [IMP]
- embryonic skeletal system morphogenesis [IMP]
- heart development [IMP]
- heart morphogenesis [IMP]
- negative regulation of transcription from RNA polymerase II promoter [IMP]
- positive regulation of bone mineralization involved in bone maturation [IMP]
- positive regulation of fat cell differentiation [ISO]
- positive regulation of histone H3-K27 trimethylation [IMP]
- positive regulation of osteoclast differentiation [IMP]
- positive regulation of peroxisome proliferator activated receptor signaling pathway [ISO]
- positive regulation of transcription from RNA polymerase II promoter [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Loss of the tumor suppressor BAP1 causes myeloid transformation.
De-ubiquitinating enzyme BAP1 is mutated in a hereditary cancer syndrome with increased risk of mesothelioma and uveal melanoma. Somatic BAP1 mutations occur in various malignancies. We show that mouse Bap1 gene deletion is lethal during embryogenesis, but systemic or hematopoietic-restricted deletion in adults recapitulates features of human myelodysplastic syndrome (MDS). Knockin mice expressing BAP1 with a 3xFlag tag revealed that ... [more]
Science Sep. 21, 2012; 337(6101);1541-6 [Pubmed: 22878500]
Throughput
- Low Throughput
Curated By
- BioGRID