TTN
Gene Ontology Biological Process
- blood coagulation [TAS]
- cardiac muscle contraction [IMP]
- cardiac muscle fiber development [IMP]
- cardiac muscle hypertrophy [IMP]
- cardiac muscle tissue morphogenesis [IMP]
- cardiac myofibril assembly [IMP]
- detection of muscle stretch [TAS]
- mitotic chromosome condensation [IEP]
- muscle contraction [NAS, TAS]
- muscle filament sliding [TAS]
- platelet activation [TAS]
- platelet degranulation [TAS]
- regulation of catalytic activity [IMP]
- regulation of protein kinase activity [IMP]
- response to calcium ion [IDA]
- sarcomere organization [IMP]
- sarcomerogenesis [IMP]
- skeletal muscle myosin thick filament assembly [IMP]
- skeletal muscle thin filament assembly [IMP]
- striated muscle contraction [TAS]
Gene Ontology Molecular Function- actin filament binding [IDA]
- actinin binding [IDA, IPI]
- calcium ion binding [IDA]
- calmodulin binding [IPI, TAS]
- enzyme binding [IPI]
- identical protein binding [IPI]
- muscle alpha-actinin binding [IPI]
- protease binding [IPI]
- protein binding [IPI]
- protein kinase binding [IPI]
- protein self-association [IDA]
- protein serine/threonine kinase activity [IDA]
- structural constituent of muscle [IMP, TAS]
- structural molecule activity conferring elasticity [TAS]
- telethonin binding [IPI, ISS]
- actin filament binding [IDA]
- actinin binding [IDA, IPI]
- calcium ion binding [IDA]
- calmodulin binding [IPI, TAS]
- enzyme binding [IPI]
- identical protein binding [IPI]
- muscle alpha-actinin binding [IPI]
- protease binding [IPI]
- protein binding [IPI]
- protein kinase binding [IPI]
- protein self-association [IDA]
- protein serine/threonine kinase activity [IDA]
- structural constituent of muscle [IMP, TAS]
- structural molecule activity conferring elasticity [TAS]
- telethonin binding [IPI, ISS]
Gene Ontology Cellular Component
CRYAB
Gene Ontology Biological Process
Gene Ontology Molecular Function
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Association of the chaperone alphaB-crystallin with titin in heart muscle.
alphaB-crystallin, a major component of the vertebrate lens, is a chaperone belonging to the family of small heat shock proteins. These proteins form oligomers that bind to partially unfolded substrates and prevent denaturation. alphaB-crystallin in cardiac muscle binds to myofibrils under conditions of ischemia, and previous work has shown that the protein binds to titin in the I-band of cardiac ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID