BAIT
PML
1200009E24Rik, AI661194, Trim19
promyelocytic leukemia
GO Process (56)
GO Function (9)
GO Component (10)
Gene Ontology Biological Process
- DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest [IMP]
- PML body organization [IDA, ISO]
- SMAD protein import into nucleus [IMP]
- activation of cysteine-type endopeptidase activity involved in apoptotic process [IMP]
- apoptotic process [ISO]
- branching involved in mammary gland duct morphogenesis [IMP]
- cell aging [IMP]
- cell cycle arrest [IMP, ISO]
- cell fate commitment [IMP]
- cellular response to interleukin-4 [IDA]
- cellular senescence [ISO]
- circadian regulation of gene expression [IDA]
- common-partner SMAD protein phosphorylation [IMP]
- endoplasmic reticulum calcium ion homeostasis [IMP]
- entrainment of circadian clock by photoperiod [IDA]
- extrinsic apoptotic signaling pathway [IMP]
- innate immune response [IDA, ISO]
- intrinsic apoptotic signaling pathway by p53 class mediator [IMP]
- intrinsic apoptotic signaling pathway in response to DNA damage [IMP, ISO]
- intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [IMP]
- intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [IMP]
- intrinsic apoptotic signaling pathway in response to oxidative stress [IMP]
- maintenance of protein location in nucleus [ISO]
- myeloid cell differentiation [IMP]
- negative regulation of angiogenesis [IMP, ISO]
- negative regulation of cell growth [ISO]
- negative regulation of cell proliferation [IMP, ISO]
- negative regulation of mitotic cell cycle [ISO]
- negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process [ISO]
- negative regulation of telomerase activity [ISO]
- negative regulation of telomere maintenance via telomerase [ISO]
- negative regulation of transcription, DNA-templated [ISO]
- negative regulation of translation in response to oxidative stress [ISO]
- negative regulation of viral release from host cell [IDA, ISO]
- positive regulation of apoptotic process involved in mammary gland involution [ISO]
- positive regulation of apoptotic signaling pathway [IGI, IMP]
- positive regulation of defense response to virus by host [ISO]
- positive regulation of extrinsic apoptotic signaling pathway [ISO]
- positive regulation of histone deacetylation [ISO]
- proteasome-mediated ubiquitin-dependent protein catabolic process [ISO]
- protein complex assembly [ISO]
- protein stabilization [ISO]
- protein targeting [ISO]
- regulation of MHC class I biosynthetic process [IDA]
- regulation of calcium ion transport into cytosol [IMP]
- regulation of circadian rhythm [IDA]
- regulation of double-strand break repair [ISO]
- regulation of nucleic acid-templated transcription [TAS]
- regulation of protein phosphorylation [IMP]
- regulation of transcription, DNA-templated [IDA, ISO]
- response to UV [IMP]
- response to cytokine [ISO]
- response to gamma radiation [IMP]
- response to hypoxia [IMP, ISO]
- retinoic acid receptor signaling pathway [IMP]
- transforming growth factor beta receptor signaling pathway [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
MTOR
2610315D21Rik, AI327068, FRAP, FRAP2, Frap1, RAFT1, RAPT1, flat, RP23-423L9.1
mechanistic target of rapamycin (serine/threonine kinase)
GO Process (41)
GO Function (11)
GO Component (13)
Gene Ontology Biological Process
- TOR signaling [ISO]
- cell growth [ISO]
- cell projection organization [IMP, ISO]
- cellular response to hypoxia [IDA]
- cellular response to nutrient levels [IDA]
- double-strand break repair via homologous recombination [IBA]
- germ cell development [IDA]
- negative regulation of NFAT protein import into nucleus [IMP]
- negative regulation of autophagy [IMP]
- negative regulation of cell size [IGI, ISO]
- negative regulation of macroautophagy [IMP]
- peptidyl-serine phosphorylation [IMP, ISO]
- peptidyl-threonine phosphorylation [IDA]
- phosphorylation [ISO]
- positive regulation of actin filament polymerization [IDA, IMP]
- positive regulation of endothelial cell proliferation [ISO]
- positive regulation of gene expression [ISO]
- positive regulation of lamellipodium assembly [IDA]
- positive regulation of lipid biosynthetic process [ISO]
- positive regulation of myotube differentiation [IGI]
- positive regulation of peptidyl-tyrosine phosphorylation [IMP]
- positive regulation of protein kinase B signaling [ISO]
- positive regulation of protein phosphorylation [ISO]
- positive regulation of stress fiber assembly [IDA]
- positive regulation of transcription from RNA polymerase III promoter [ISO]
- positive regulation of translation [ISO]
- protein autophosphorylation [ISO]
- protein phosphorylation [ISO]
- regulation of Rac GTPase activity [IMP]
- regulation of actin cytoskeleton organization [ISO]
- regulation of carbohydrate metabolic process [ISO]
- regulation of carbohydrate utilization [ISO]
- regulation of fatty acid beta-oxidation [ISO]
- regulation of glycogen biosynthetic process [ISO]
- regulation of myelination [IMP]
- regulation of protein kinase activity [IGI]
- regulation of response to food [ISO]
- response to amino acid [IDA, ISO]
- response to insulin [IDA]
- response to stress [ISO]
- ruffle organization [IDA]
Gene Ontology Molecular Function- RNA polymerase III type 1 promoter DNA binding [ISO]
- RNA polymerase III type 2 promoter DNA binding [ISO]
- RNA polymerase III type 3 promoter DNA binding [ISO]
- TFIIIC-class transcription factor binding [ISO]
- kinase activity [ISO]
- phosphoprotein binding [ISO]
- protein binding [IPI]
- protein dimerization activity [IBA]
- protein domain specific binding [ISO]
- protein serine/threonine kinase activity [IDA, ISO]
- ribosome binding [IDA]
- RNA polymerase III type 1 promoter DNA binding [ISO]
- RNA polymerase III type 2 promoter DNA binding [ISO]
- RNA polymerase III type 3 promoter DNA binding [ISO]
- TFIIIC-class transcription factor binding [ISO]
- kinase activity [ISO]
- phosphoprotein binding [ISO]
- protein binding [IPI]
- protein dimerization activity [IBA]
- protein domain specific binding [ISO]
- protein serine/threonine kinase activity [IDA, ISO]
- ribosome binding [IDA]
Gene Ontology Cellular Component
Mus musculus
Co-localization
Interaction inferred from two proteins that co-localize in the cell by indirect immunofluorescence only when in addition, if one gene is deleted, the other protein becomes mis-localized. Also includes co-dependent association of proteins with promoter DNA in chromatin immunoprecipitation experiments.
Publication
PML inhibits HIF-1alpha translation and neoangiogenesis through repression of mTOR.
Loss of the promyelocytic leukaemia (PML) tumour suppressor has been observed in several human cancers. The tumour-suppressive function of PML has been attributed to its ability to induce growth arrest, cellular senescence and apoptosis. Here we identify PML as a critical inhibitor of neoangiogenesis (the formation of new blood vessels) in vivo, in both ischaemic and neoplastic conditions, through the ... [more]
Nature Aug. 17, 2006; 442(7104);779-85 [Pubmed: 16915281]
Throughput
- Low Throughput
Additional Notes
- protein co-localization increases upon hypoxia
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| PML MTOR | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | 282569 |
Curated By
- BioGRID