JAK2
Gene Ontology Biological Process
- JAK-STAT cascade [TAS]
- JAK-STAT cascade involved in growth hormone signaling pathway [ISS, TAS]
- STAT protein import into nucleus [ISS]
- actin filament polymerization [NAS]
- activation of JAK2 kinase activity [ISS]
- activation of cysteine-type endopeptidase activity involved in apoptotic process [ISS]
- activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway [ISS]
- apoptotic process [ISS]
- blood coagulation [TAS]
- cell differentiation [ISS]
- cell migration [IBA]
- cellular component movement [TAS]
- cytokine-mediated signaling pathway [IDA, ISS, TAS]
- enzyme linked receptor protein signaling pathway [ISS]
- erythrocyte differentiation [IBA, ISS]
- extrinsic apoptotic signaling pathway [ISS]
- growth hormone receptor signaling pathway [IDA]
- histone H3-Y41 phosphorylation [IDA]
- innate immune response [IBA]
- interferon-gamma-mediated signaling pathway [TAS]
- interleukin-12-mediated signaling pathway [IDA]
- intracellular signal transduction [ISS]
- mammary gland epithelium development [ISS]
- mesoderm development [TAS]
- negative regulation of DNA binding [ISS]
- negative regulation of cell proliferation [ISS]
- peptidyl-tyrosine autophosphorylation [IBA]
- peptidyl-tyrosine phosphorylation [ISS]
- positive regulation of cell-substrate adhesion [IDA]
- positive regulation of growth hormone receptor signaling pathway [ISS]
- positive regulation of nitric-oxide synthase biosynthetic process [ISS]
- positive regulation of peptidyl-tyrosine phosphorylation [ISS]
- positive regulation of phosphatidylinositol 3-kinase signaling [ISS]
- positive regulation of tumor necrosis factor production [ISS]
- positive regulation of tyrosine phosphorylation of Stat3 protein [ISS]
- positive regulation of tyrosine phosphorylation of Stat5 protein [ISS]
- protein autophosphorylation [ISS]
- protein phosphorylation [TAS]
- regulation of apoptotic process [IBA]
- regulation of cell proliferation [IBA]
- regulation of inflammatory response [IDA]
- regulation of interferon-gamma-mediated signaling pathway [TAS]
- response to antibiotic [IDA]
- response to interleukin-12 [IDA]
- response to lipopolysaccharide [ISS]
- response to tumor necrosis factor [IDA]
- signal transduction [ISS]
- tumor necrosis factor-mediated signaling pathway [IDA]
- tyrosine phosphorylation of STAT protein [IBA, ISS]
Gene Ontology Molecular Function- SH2 domain binding [IPI]
- growth hormone receptor binding [IBA, ISS]
- heme binding [IDA]
- histone binding [IDA]
- histone kinase activity (H3-Y41 specific) [IDA]
- interleukin-12 receptor binding [ISS]
- non-membrane spanning protein tyrosine kinase activity [IBA]
- protein binding [IPI]
- protein kinase activity [NAS]
- protein kinase binding [IDA]
- protein tyrosine kinase activity [EXP, ISS, TAS]
- receptor binding [IPI]
- SH2 domain binding [IPI]
- growth hormone receptor binding [IBA, ISS]
- heme binding [IDA]
- histone binding [IDA]
- histone kinase activity (H3-Y41 specific) [IDA]
- interleukin-12 receptor binding [ISS]
- non-membrane spanning protein tyrosine kinase activity [IBA]
- protein binding [IPI]
- protein kinase activity [NAS]
- protein kinase binding [IDA]
- protein tyrosine kinase activity [EXP, ISS, TAS]
- receptor binding [IPI]
Gene Ontology Cellular Component
MAP3K5
Gene Ontology Biological Process
- JNK cascade [IDA]
- MAPK cascade [IDA]
- activation of JUN kinase activity [TAS]
- activation of MAPKK activity [IDA]
- activation of cysteine-type endopeptidase activity involved in apoptotic process [IDA]
- apoptotic signaling pathway [TAS]
- cellular response to hydrogen peroxide [IDA]
- intrinsic apoptotic signaling pathway in response to oxidative stress [IDA]
- positive regulation of apoptotic process [IDA]
- positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [IDA]
- positive regulation of neuron death [IGI]
- protein phosphorylation [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Biochemical Activity (Phosphorylation)
An interaction is inferred from the biochemical effect of one protein upon another, for example, GTP-GDP exchange activity or phosphorylation of a substrate by a kinase. The bait protein executes the activity on the substrate hit protein. A Modification value is recorded for interactions of this type with the possible values Phosphorylation, Ubiquitination, Sumoylation, Dephosphorylation, Methylation, Prenylation, Acetylation, Deubiquitination, Proteolytic Processing, Glucosylation, Nedd(Rub1)ylation, Deacetylation, No Modification, Demethylation.
Publication
JAK2 and SHP2 reciprocally regulate tyrosine phosphorylation and stability of proapoptotic protein ASK1.
Previously we have shown that tyrosine 718 of ASK1 when phosphorylated is critical for SOCS1 binding and SOCS1-mediated degradation of ASK1. However, the kinase and phosphatase responsible for phosphorylation and dephosphorylation of ASK1 at Tyr-718 are unknown. In this study, we identified JAK2 and SHP2 as a Tyr-718-specific kinase and phosphatase, respectively. Interferon-gamma (IFN-gamma) induced degradation of ASK1 in normal ... [more]
Throughput
- Low Throughput
Related interactions
Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
---|---|---|---|---|---|---|
JAK2 MAP3K5 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - |
Curated By
- BioGRID