SNCA
Gene Ontology Biological Process
- activation of cysteine-type endopeptidase activity involved in apoptotic process [ISO]
- adult locomotory behavior [IGI]
- behavioral response to cocaine [ISO]
- cellular response to copper ion [ISO]
- cellular response to oxidative stress [IMP]
- dopamine biosynthetic process [IMP]
- dopamine metabolic process [IGI]
- fatty acid metabolic process [IMP]
- long-term synaptic potentiation [IMP]
- membrane organization [IMP]
- microglial cell activation [IMP]
- mitochondrial ATP synthesis coupled electron transport [IMP]
- mitochondrial membrane organization [IMP]
- negative regulation of apoptotic process [ISO]
- negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [ISO]
- negative regulation of dopamine metabolic process [ISO]
- negative regulation of dopamine uptake involved in synaptic transmission [ISO]
- negative regulation of exocytosis [ISO]
- negative regulation of histone acetylation [ISO]
- negative regulation of microtubule polymerization [ISO]
- negative regulation of monooxygenase activity [ISO]
- negative regulation of neuron apoptotic process [IGI, ISO]
- negative regulation of norepinephrine uptake [ISO]
- negative regulation of platelet-derived growth factor receptor signaling pathway [ISO]
- negative regulation of protein phosphorylation [ISO]
- negative regulation of serotonin uptake [ISO]
- negative regulation of thrombin receptor signaling pathway [ISO]
- negative regulation of transporter activity [ISO]
- neutral lipid metabolic process [IMP]
- oxidation-reduction process [ISO]
- phospholipid metabolic process [IMP]
- positive regulation of endocytosis [ISO]
- positive regulation of glutathione peroxidase activity [ISO]
- positive regulation of hydrogen peroxide catabolic process [ISO]
- positive regulation of inositol phosphate biosynthetic process [ISO]
- positive regulation of neurotransmitter secretion [IDA]
- positive regulation of peptidyl-serine phosphorylation [IMP]
- positive regulation of protein serine/threonine kinase activity [ISO]
- positive regulation of receptor recycling [ISO]
- positive regulation of release of sequestered calcium ion into cytosol [ISO]
- positive regulation of synaptic transmission [IMP]
- protein destabilization [ISO]
- receptor internalization [ISO]
- regulation of acyl-CoA biosynthetic process [IDA, IMP]
- regulation of dopamine secretion [IGI]
- regulation of excitatory postsynaptic membrane potential [IMP]
- regulation of glutamate secretion [IMP]
- regulation of locomotion [IMP]
- regulation of long-term neuronal synaptic plasticity [IMP]
- regulation of macrophage activation [IMP]
- regulation of neuron apoptotic process [IMP]
- regulation of neuron death [ISO]
- regulation of neuronal synaptic plasticity [IMP]
- regulation of neurotransmitter secretion [IGI, IMP]
- regulation of phospholipase activity [ISO]
- response to drug [IMP]
- response to interferon-gamma [ISO]
- response to interleukin-1 [ISO]
- response to iron(II) ion [ISO]
- response to lipopolysaccharide [ISO]
- response to magnesium ion [ISO]
- synapse organization [IGI]
- synaptic transmission [IGI]
- synaptic transmission, dopaminergic [IMP]
- synaptic vesicle endocytosis [IMP]
- synaptic vesicle transport [IMP]
Gene Ontology Molecular Function- Hsp70 protein binding [ISO]
- alpha-tubulin binding [ISO]
- arachidonic acid binding [IDA]
- beta-tubulin binding [ISO]
- calcium ion binding [ISO]
- copper ion binding [ISO]
- cysteine-type endopeptidase inhibitor activity involved in apoptotic process [ISO]
- dynein binding [ISO]
- enzyme binding [ISO]
- ferrous iron binding [ISO]
- histone binding [IDA, ISO]
- identical protein binding [IDA, ISO]
- kinesin binding [ISO]
- magnesium ion binding [ISO]
- microtubule binding [ISO]
- oxidoreductase activity [ISO]
- phospholipase binding [ISO]
- phospholipid binding [ISO]
- phosphoprotein binding [ISO]
- protein N-terminus binding [ISO]
- protein binding [IPI]
- protein domain specific binding [ISO]
- tau protein binding [ISO]
- zinc ion binding [ISO]
- Hsp70 protein binding [ISO]
- alpha-tubulin binding [ISO]
- arachidonic acid binding [IDA]
- beta-tubulin binding [ISO]
- calcium ion binding [ISO]
- copper ion binding [ISO]
- cysteine-type endopeptidase inhibitor activity involved in apoptotic process [ISO]
- dynein binding [ISO]
- enzyme binding [ISO]
- ferrous iron binding [ISO]
- histone binding [IDA, ISO]
- identical protein binding [IDA, ISO]
- kinesin binding [ISO]
- magnesium ion binding [ISO]
- microtubule binding [ISO]
- oxidoreductase activity [ISO]
- phospholipase binding [ISO]
- phospholipid binding [ISO]
- phosphoprotein binding [ISO]
- protein N-terminus binding [ISO]
- protein binding [IPI]
- protein domain specific binding [ISO]
- tau protein binding [ISO]
- zinc ion binding [ISO]
Gene Ontology Cellular Component
- Golgi apparatus [ISO]
- actin cytoskeleton [ISO]
- axon [ISO]
- axon terminus [ISO]
- cell [IMP]
- cell cortex [ISO]
- cytoplasm [IDA, ISO]
- cytoplasmic vesicle membrane [ISO]
- cytoskeleton [IDA]
- cytosol [IDA, ISO]
- fibril [ISO]
- growth cone [ISO]
- inclusion body [IDA, ISO]
- intracellular membrane-bounded organelle [ISO]
- mitochondrion [IMP, ISO]
- nuclear outer membrane [ISO]
- nucleus [IDA, ISO]
- perinuclear region of cytoplasm [ISO]
- plasma membrane [IDA, ISO]
- platelet alpha granule membrane [ISO]
- ribosome [ISO]
- rough endoplasmic reticulum [ISO]
- synapse [IDA]
- synaptic vesicle [ISO]
- terminal bouton [ISO]
KCNJ11
Gene Ontology Biological Process
- glucose metabolic process [ISO]
- negative regulation of insulin secretion [ISO]
- neurological system process [ISO]
- positive regulation of cation channel activity [ISO]
- potassium ion import [IDA]
- potassium ion transmembrane transport [ISO]
- potassium ion transport [ISO]
- regulation of insulin secretion [ISO]
- regulation of ion transmembrane transport [IDA]
- regulation of membrane potential [ISO]
- response to ATP [ISO]
- response to drug [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- ATP-sensitive potassium channel complex [IDA, ISO]
- T-tubule [IDA, ISO]
- axolemma [ISO]
- cell body fiber [ISO]
- cytosol [ISO]
- endoplasmic reticulum [ISO]
- endosome [ISO]
- intercalated disc [ISO]
- intracellular membrane-bounded organelle [ISO]
- mitochondrion [ISO]
- myelin sheath [ISO]
- neuronal cell body [ISO]
- nuclear envelope [ISO]
- plasma membrane [IDA, ISO]
- sarcolemma [ISO]
- voltage-gated potassium channel complex [ISO]
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
α-Synuclein binds the K(ATP) channel at insulin-secretory granules and inhibits insulin secretion.
α-Synuclein has been studied in numerous cell types often associated with secretory processes. In pancreatic β-cells, α-synuclein might therefore play a similar role by interacting with organelles involved in insulin secretion. We tested for α-synuclein localizing to insulin-secretory granules and characterized its role in glucose-stimulated insulin secretion. Immunohistochemistry and fluorescent sulfonylureas were used to test for α-synuclein localization to insulin ... [more]
Throughput
- Low Throughput
Additional Notes
- figure 5.
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| KCNJ11 SNCA | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | 725090 | |
| SNCA KCNJ11 | Co-localization Co-localization Interaction inferred from two proteins that co-localize in the cell by indirect immunofluorescence only when in addition, if one gene is deleted, the other protein becomes mis-localized. Also includes co-dependent association of proteins with promoter DNA in chromatin immunoprecipitation experiments. | Low | - | BioGRID | 725086 |
Curated By
- BioGRID